{"id":140,"date":"2025-04-28T17:42:32","date_gmt":"2025-04-28T17:42:32","guid":{"rendered":"https:\/\/honeydew-hyena-350809.hostingersite.com\/?page_id=140"},"modified":"2025-05-08T14:49:21","modified_gmt":"2025-05-08T14:49:21","slug":"about-spg3a","status":"publish","type":"page","link":"https:\/\/kidswithspg3a.com\/es\/about-spg3a\/","title":{"rendered":"Acerca de SPG3A"},"content":{"rendered":"
<\/div>\n\n\n\n

\u00bfQU\u00c9 ES LA PARAPLEJ\u00cdA ESP\u00c1STICA 3A?<\/h1>\n\n\n\n

SPG3A (tambi\u00e9n conocida como ATL1-HSP) es el tipo m\u00e1s com\u00fan de HSP autos\u00f3mica dominante en ni\u00f1os. La edad promedio de inicio para SPG3A es de 4 a\u00f1os, y m\u00e1s del 80% de los casos muestran s\u00edntomas antes de los 10 a\u00f1os.

SPG3A es un subtipo de un grupo de condiciones neurol\u00f3gicas raras llamadas Paraplej\u00eda Esp\u00e1stica Hereditaria. Las paraplej\u00edas esp\u00e1sticas hereditarias a menudo se dividen en dos tipos: puras y complejas. Los tipos puros afectan solo las extremidades inferiores, mientras que los tipos complejos tambi\u00e9n afectan otras \u00e1reas del cuerpo, como las extremidades superiores y los m\u00fasculos motores orales, y pueden presentar otros s\u00edntomas como convulsiones y cambios en el funcionamiento intelectual.

Las mutaciones en el gen ATL-1 (Atlastina-1) causan SPG3A. Estas mutaciones probablemente conducen a una actividad anormal de la atlastina-1, lo que afecta el funcionamiento de las neuronas, incluida la distribuci\u00f3n de materiales dentro de estas c\u00e9lulas. Esta falta de prote\u00edna atlastina-1 funcional tambi\u00e9n puede restringir el crecimiento de axones. Dentro de las neuronas largas de los tractos corticospinales, estos problemas pueden provocar la muerte celular. Como resultado, las neuronas no pueden transmitir impulsos nerviosos, particularmente a otras neuronas y m\u00fasculos en las extremidades inferiores. Esta funci\u00f3n nerviosa alterada lleva a los signos y s\u00edntomas de la paraplej\u00eda esp\u00e1stica tipo 3A.

La mayor\u00eda de las personas con SPG3A (>95%) tienen un progenitor afectado. En otras palabras, heredan la mutaci\u00f3n gen\u00e9tica de al menos uno de los padres. En algunas personas, la mutaci\u00f3n ocurre \u00abde novo\u00bb, es decir, el gen muta aleatoriamente durante el desarrollo embrionario y no se hereda de un progenitor.<\/p>\n\n\n\n

Fuente: Instituto Nacional de Salud, Biblioteca Nacional de Medicina, MedlinePlus<\/p>\n\n\n\n

\"\"
Fuente: Paraplej\u00eda Esp\u00e1stica Hereditaria: Una Actualizaci\u00f3n por el Dr. Arun Meyyazhagan<\/figcaption><\/figure>","protected":false},"excerpt":{"rendered":"

\u00bfQU\u00c9 ES LA PARAPLEJ\u00cdA ESP\u00c1STICA 3A? SPG3A (tambi\u00e9n conocida como ATL1-HSP) es el tipo m\u00e1s com\u00fan de HSP autos\u00f3mica dominante en ni\u00f1os. La edad promedio de inicio para SPG3A es de 4 a\u00f1os, y m\u00e1s del 80% de los casos muestran s\u00edntomas antes de los 10 a\u00f1os. SPG3A es un subtipo de un grupo de […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ghostkit_customizer_options":"","ghostkit_custom_css":"","ghostkit_custom_js_head":"","ghostkit_custom_js_foot":"","ghostkit_typography":"","footnotes":""},"class_list":["post-140","page","type-page","status-publish","hentry"],"blocksy_meta":{"background":{"background_type":"image","background_pattern":"type-1","background_image":{"attachment_id":142,"x":0,"y":0,"url":"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635bd3421cfdc0509b3cd923_Artboard-min.png"},"gradient":"linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 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