{"id":150,"date":"2025-04-28T17:51:29","date_gmt":"2025-04-28T17:51:29","guid":{"rendered":"https:\/\/honeydew-hyena-350809.hostingersite.com\/?page_id=150"},"modified":"2025-05-08T12:59:25","modified_gmt":"2025-05-08T12:59:25","slug":"research","status":"publish","type":"page","link":"https:\/\/kidswithspg3a.com\/es\/research\/","title":{"rendered":"Investigaci\u00f3n"},"content":{"rendered":"<!-- wp:spacer -->\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:group {\"style\":{\"color\":{\"background\":\"#ffffff91\"}},\"layout\":{\"type\":\"constrained\"}} -->\n<div class=\"wp-block-group has-background\" style=\"background-color:#ffffff91\">\n  <!-- wp:heading {\"level\":1} -->\n  <h1 class=\"wp-block-heading\" id=\"research\">Investigaci\u00f3n<\/h1>\n  <!-- \/wp:heading -->\n\n  <!-- wp:ghostkit\/accordion {\"itemsCount\":4,\"collapseOne\":true,\"collapseTitleTag\":\"h2\"} -->\n  <div class=\"ghostkit-accordion ghostkit-accordion-4 ghostkit-accordion-collapse-one\">\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-the-carter-foundation-research-program\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-the-carter-foundation-research-program\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-the-carter-foundation-research-program-button\" aria-expanded=\"false\" aria-controls=\"accordion-the-carter-foundation-research-program-content\">\n          <span class=\"ghostkit-accordion-item-label\">El Programa de Investigaci\u00f3n de la Fundaci\u00f3n Carter<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-the-carter-foundation-research-program-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-the-carter-foundation-research-program-button\">\n        <!-- wp:embed {\"url\":\"https:\/\/www.youtube.com\/watch?v=LNd_Oog5fiU\",\"type\":\"video\",\"providerNameSlug\":\"youtube\",\"responsive\":true,\"className\":\"wp-embed-aspect-16-9 wp-has-aspect-ratio\"} -->\n        <figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\">\n          <div class=\"wp-block-embed__wrapper\">\n            <iframe loading=\"lazy\" title=\"Carter Foundation SPG3A Research Program Update - February 2025\" width=\"1290\" height=\"726\" src=\"https:\/\/www.youtube.com\/embed\/LNd_Oog5fiU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n          <\/div>\n        <\/figure>\n        <!-- \/wp:embed -->\n\n        <!-- wp:paragraph -->\n        <p>La misi\u00f3n de <strong>la Fundaci\u00f3n Carter<\/strong> es facilitar el desarrollo de terapias y tratamientos para ni\u00f1os con Paraplej\u00eda Esp\u00e1stica Hereditaria (HSP). Actualmente, se centra en las dos formas m\u00e1s comunes de HSP, SPG3A y SPG4, con \u00e9nfasis en aquellas mutaciones con inicio temprano y, a menudo, condiciones de novo.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>El esfuerzo de la Fundaci\u00f3n es cerrar la brecha entre la comprensi\u00f3n b\u00e1sica celular y gen\u00e9tica de estas condiciones y el desarrollo de terapias. Esto se conoce como Medicina Traslacional. Esto implica tomar el conocimiento cient\u00edfico b\u00e1sico actual de estas condiciones y probar hip\u00f3tesis terap\u00e9uticas en modelos animales vivos. Con un modelo animal reproducible, las empresas biofarmac\u00e9uticas y los institutos pueden llevar a cabo el desarrollo terap\u00e9utico formal y ensayos cl\u00ednicos.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>En este video, los doctores Blackstone y Avellone discuten <strong>los \u00faltimos avances del Programa de Investigaci\u00f3n de la Fundaci\u00f3n Carter<\/strong>, que est\u00e1 estudiando las siguientes cuatro hip\u00f3tesis terap\u00e9uticas en el modelo de rat\u00f3n SPG3A desarrollado en Jackson Laboratories:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>&#8211; Agentes de modulaci\u00f3n lip\u00eddica<br>&#8211; Inhibici\u00f3n de la v\u00eda de se\u00f1alizaci\u00f3n de la Prote\u00edna Morfog\u00e9nica \u00d3sea (BMP)<br>&#8211; Terapias de Oligonucle\u00f3tidos Antisentido (ASO)<br>&#8211; Edici\u00f3n gen\u00e9tica avanzada (edici\u00f3n de bases)<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Plazo esperado: 1-2 a\u00f1os. Sin embargo, a medida que se observen resultados preliminares prometedores, el plan ser\u00e1 iniciar discusiones con empresas biofarmac\u00e9uticas e institutos relevantes en paralelo.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/www.massgeneral.org\/doctors\/21073\/craig-blackstone\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Dr. Craig Blackstone<\/strong><\/a> es el Jefe de la Divisi\u00f3n de Trastornos del Movimiento en el Massachusetts General Hospital (MGH) y Profesor de Neurolog\u00eda en la Escuela de Medicina de Harvard. Antes de llegar al MGH en 2020, el Dr. Blackstone pas\u00f3 20 a\u00f1os en los Institutos Nacionales de Salud, finalmente como Investigador Principal y Jefe de la Secci\u00f3n de Biolog\u00eda Celular dentro de la Rama de Neurogen\u00e9tica. Bajo su liderazgo, su grupo investig\u00f3 los mecanismos celulares y moleculares de los trastornos del movimiento heredados. Es uno de los principales investigadores del mundo en este campo.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Joseph_Avellone)\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Dr. Joseph Avellone<\/strong><\/a>, un cirujano retirado y ejecutivo de atenci\u00f3n m\u00e9dica, tiene un nieto, Carter, que padece SPG3A complejo de novo. Junto con otros miembros de la familia, fund\u00f3 la <strong>Fundaci\u00f3n Carter para la Investigaci\u00f3n Neurol\u00f3gica<\/strong>.<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-early-onset-hsp-natural-history-study\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-early-onset-hsp-natural-history-study\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-early-onset-hsp-natural-history-study-button\" aria-expanded=\"false\" aria-controls=\"accordion-early-onset-hsp-natural-history-study-content\">\n          <span class=\"ghostkit-accordion-item-label\">Estudio de Historia Natural de HSP de Inicio Temprano<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-early-onset-hsp-natural-history-study-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-early-onset-hsp-natural-history-study-button\">\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/connects.catalyst.harvard.edu\/Profiles\/display\/Person\/125033\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Dr. Darius Ebrahimi-Fakhari<\/strong><\/a> del <a href=\"https:\/\/www.childrenshospital.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Hospital Infantil de Boston<\/strong><\/a> est\u00e1 creando <a href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>un registro de todas las Paraplej\u00edas Esp\u00e1sticas Hereditarias de inicio en la infancia<\/strong><\/a> (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04712812?cond=NCT04712812&#038;draw=2&#038;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\">Registro y Estudio de Historia Natural para la Paraplej\u00eda Esp\u00e1stica Hereditaria de Inicio Temprano<\/a>).<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Los estudios de historia natural son cr\u00edticos para las enfermedades raras. Sin ellos, no estar\u00e1n disponibles opciones de tratamiento. Los ensayos cl\u00ednicos futuros relacionados con curas para la HSP infantil, incluidos aquellos que podr\u00edan surgir del programa de investigaci\u00f3n de la Fundaci\u00f3n Carter para la Investigaci\u00f3n Neurol\u00f3gica, probablemente depender\u00e1n de este registro.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><strong>El estudio a\u00fan busca participantes a nivel mundial.<\/strong> A partir de agosto de 2022, <a href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>el registro ten\u00eda solo 11 casos de SPG3A<\/strong>.<\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Si tiene SPG3A y a\u00fan no se ha registrado, le recomendamos encarecidamente que se comunique con <br><a href=\"http:\/\/sahin-lab.org\/people\/catherine-jordan-ms\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Amy Tam<\/strong><\/a>, la Coordinadora del Estudio, en su correo electr\u00f3nico:<br><a href=\"http:\/\/Catherine.Jordan@childrens.harvard.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>amy.tam@childrens.harvard.edu<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>La participaci\u00f3n es GRATUITA e implica una consulta de 1 hora por Zoom con el Dr. Darius.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Criterios de inclusi\u00f3n:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:list -->\n        <ul class=\"wp-block-list\">\n          <!-- wp:list-item -->\n          <li>Inicio de los s\u00edntomas de la paraplej\u00eda esp\u00e1stica hereditaria antes de los 18 a\u00f1os<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>Edad actual menor a 30 a\u00f1os<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>Tener variantes en genes relacionados con HSP y\/o un familiar con dicho diagn\u00f3stico<\/li>\n          <!-- \/wp:list-item -->\n        <\/ul>\n        <!-- \/wp:list -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\" aria-expanded=\"false\" aria-controls=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\">\n          <span class=\"ghostkit-accordion-item-label\">Conclusiones para SPG3A del Simposio sobre SPG4 de Novo Organizado por los NIH<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.219-BrownC9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\">\n        <!-- wp:paragraph -->\n        <p>El Dr. Craig Blackstone del Massachusetts General Hospital en Boston es uno de los principales investigadores en HSP, espec\u00edficamente en SPG3A.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>En colaboraci\u00f3n con la Fundaci\u00f3n Carter para la Investigaci\u00f3n de Enfermedades Neurol\u00f3gicas, est\u00e1 probando, tanto en modelos in vitro como in vivo, diversos compuestos farmacol\u00f3gicos y m\u00e9todos de terapia g\u00e9nica con el objetivo de dise\u00f1ar ensayos cl\u00ednicos en ni\u00f1os con SPG3A de novo en un futuro pr\u00f3ximo.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Puede ver la presentaci\u00f3n de la investigaci\u00f3n del Dr. Blackstone aqu\u00ed, comenzando en el minuto 24:32: <a href=\"https:\/\/videocast.nih.gov\/watch=44694\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/videocast.nih.gov\/watch=44694<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Aqu\u00ed hay una instant\u00e1nea de su presentaci\u00f3n:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>El Dr. Blackstone y la Fundaci\u00f3n Carter depender\u00e1n del Estudio de Historia Natural de HSP del Hospital Infantil de Boston (descrito anteriormente) para dise\u00f1ar cualquier ensayo cl\u00ednico futuro.<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-mutational-cluster-causing-more-severe-spg3a\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-mutational-cluster-causing-more-severe-spg3a\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\" aria-expanded=\"false\" aria-controls=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\">\n          <span class=\"ghostkit-accordion-item-label\">Grupo de Mutaciones que Causa un SPG3A M\u00e1s Grave<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\">\n        <!-- wp:paragraph -->\n        <p>Los investigadores Julian E. Alecu, Afshin Saffari, Catherine Jordan, Siddharth Srivastava, Craig Blackstone y Darius Ebrahimi-Fakhari realizaron un an\u00e1lisis transversal de 537 pacientes con SPG3A, incluidos 31 con variantes de novo de ATL1.<br><br>Identificaron que ciertas variantes, ubicadas dentro de un grupo de mutaciones tridimensional, causan s\u00edntomas m\u00e1s graves que van m\u00e1s all\u00e1 de la HSP pura que afecta solo a las extremidades inferiores. Los s\u00edntomas m\u00e1s complejos incluyen anomal\u00edas del neurodesarrollo, espasticidad de las extremidades superiores, s\u00edntomas bulbares (disartria, disfagia, etc.), neuropat\u00eda perif\u00e9rica y anomal\u00edas en im\u00e1genes cerebrales.<br><br>Las variantes identificadas en este grupo son <strong>Ala350, Arg403, Arg415, Arg416, Asn355, Gly409, Gly410, Leu401, Lys407, Met347, Met408, Phe413, Pro344, Ser346, Ser398, Ser414, Tyr417, Val405<\/strong>.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Sus hallazgos establecen una relaci\u00f3n genotipo-fenotipo para las mutaciones de ATL1. Este grupo de mutaciones informar\u00e1 las opciones de tratamiento futuras.<br><strong>\u200d<\/strong><br>Puede leer el resumen <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35925862\/\" target=\"_blank\" rel=\"noreferrer noopener\">aqu\u00ed<\/a>.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:image {\"id\":151,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n        <figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1355\" height=\"913\" src=\"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18.png\" alt=\"\" class=\"wp-image-151\" title=\"\" srcset=\"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18.png 1355w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-300x202.png 300w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-1024x690.png 1024w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-768x517.png 768w\" sizes=\"auto, (max-width: 1355px) 100vw, 1355px\" \/><\/figure>\n        <!-- \/wp:image -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n  <\/div>\n  <!-- \/wp:ghostkit\/accordion -->\n<\/div>\n<!-- \/wp:group --><!-- \/wp:group -->","protected":false},"excerpt":{"rendered":"<p>Investigaci\u00f3n El Programa de Investigaci\u00f3n de la Fundaci\u00f3n Carter La misi\u00f3n de la Fundaci\u00f3n Carter es facilitar el desarrollo de terapias y tratamientos para ni\u00f1os con Paraplej\u00eda Esp\u00e1stica Hereditaria (HSP). Actualmente, se centra en las dos formas m\u00e1s comunes de HSP, SPG3A y SPG4, con \u00e9nfasis en aquellas mutaciones con inicio temprano y, a menudo, [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ghostkit_customizer_options":"","ghostkit_custom_css":"","ghostkit_custom_js_head":"","ghostkit_custom_js_foot":"","ghostkit_typography":"","footnotes":""},"class_list":["post-150","page","type-page","status-publish","hentry"],"blocksy_meta":{"background":{"background_type":"image","background_pattern":"type-1","background_image":{"attachment_id":154,"x":0,"y":0,"url":"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f4a6c6c5db63aa2f18407_Layer-0-1-613x1024.png"},"gradient":"linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 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