{"id":150,"date":"2025-04-28T17:51:29","date_gmt":"2025-04-28T17:51:29","guid":{"rendered":"https:\/\/honeydew-hyena-350809.hostingersite.com\/?page_id=150"},"modified":"2025-05-08T12:59:25","modified_gmt":"2025-05-08T12:59:25","slug":"research","status":"publish","type":"page","link":"https:\/\/kidswithspg3a.com\/fr\/research\/","title":{"rendered":"Recherche"},"content":{"rendered":"<!-- wp:spacer -->\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:group {\"style\":{\"color\":{\"background\":\"#ffffff91\"}},\"layout\":{\"type\":\"constrained\"}} -->\n<div class=\"wp-block-group has-background\" style=\"background-color:#ffffff91\">\n  <!-- wp:heading {\"level\":1} -->\n  <h1 class=\"wp-block-heading\" id=\"research\">Recherche<\/h1>\n  <!-- \/wp:heading -->\n\n  <!-- wp:ghostkit\/accordion {\"itemsCount\":4,\"collapseOne\":true,\"collapseTitleTag\":\"h2\"} -->\n  <div class=\"ghostkit-accordion ghostkit-accordion-4 ghostkit-accordion-collapse-one\">\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-the-carter-foundation-research-program\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-the-carter-foundation-research-program\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-the-carter-foundation-research-program-button\" aria-expanded=\"false\" aria-controls=\"accordion-the-carter-foundation-research-program-content\">\n          <span class=\"ghostkit-accordion-item-label\">Le programme de recherche de la Fondation Carter<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-the-carter-foundation-research-program-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-the-carter-foundation-research-program-button\">\n        <!-- wp:embed {\"url\":\"https:\/\/www.youtube.com\/watch?v=LNd_Oog5fiU\",\"type\":\"video\",\"providerNameSlug\":\"youtube\",\"responsive\":true,\"className\":\"wp-embed-aspect-16-9 wp-has-aspect-ratio\"} -->\n        <figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\">\n          <div class=\"wp-block-embed__wrapper\">\n            <iframe loading=\"lazy\" title=\"Carter Foundation SPG3A Research Program Update - February 2025\" width=\"1290\" height=\"726\" src=\"https:\/\/www.youtube.com\/embed\/LNd_Oog5fiU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n          <\/div>\n        <\/figure>\n        <!-- \/wp:embed -->\n\n        <!-- wp:paragraph -->\n        <p>La mission de <strong>la Fondation Carter<\/strong> est de permettre le d\u00e9veloppement de th\u00e9rapies et de traitements pour les enfants atteints de parapl\u00e9gie spastique h\u00e9r\u00e9ditaire (PSH). Elle se concentre actuellement sur les deux formes les plus courantes de PSH, SPG3A et SPG4, avec un accent particulier sur les mutations \u00e0 d\u00e9but pr\u00e9coce et souvent des conditions de novo.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>L\u2019effort de la Fondation vise \u00e0 combler l\u2019\u00e9cart entre la compr\u00e9hension cellulaire et g\u00e9n\u00e9tique de base de ces conditions et le d\u00e9veloppement de th\u00e9rapies. Cela s\u2019appelle la m\u00e9decine translationnelle. Cela signifie prendre la compr\u00e9hension scientifique de base actuelle de ces conditions et prouver des hypoth\u00e8ses th\u00e9rapeutiques dans des mod\u00e8les animaux vivants. Avec un mod\u00e8le animal reproductible, les entreprises biopharmaceutiques et les instituts peuvent entreprendre un d\u00e9veloppement th\u00e9rapeutique formel et des essais cliniques.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Dans cette vid\u00e9o, les docteurs Blackstone et Avellone discutent des <strong>derniers d\u00e9veloppements du programme de recherche de la Fondation Carter<\/strong>, qui \u00e9tudie les quatre hypoth\u00e8ses th\u00e9rapeutiques suivantes dans le mod\u00e8le murin SPG3A d\u00e9velopp\u00e9 par Jackson Laboratories :<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>&#8211; Agents de modulation lipidique<br>&#8211; Inhibition de la voie de signalisation des prot\u00e9ines morphog\u00e9n\u00e9tiques osseuses (BMP)<br>&#8211; Th\u00e9rapies par oligonucl\u00e9otides antisens (ASO)<br>&#8211; \u00c9dition g\u00e9n\u00e9tique avanc\u00e9e (\u00e9dition de bases)<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>D\u00e9lai pr\u00e9vu : 1 \u00e0 2 ans. Cependant, d\u00e8s que des r\u00e9sultats pr\u00e9coces prometteurs seront observ\u00e9s, le plan est d\u2019entamer des discussions avec les entreprises biopharmaceutiques et les instituts concern\u00e9s en parall\u00e8le.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/www.massgeneral.org\/doctors\/21073\/craig-blackstone\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Dr. Craig Blackstone<\/strong><\/a> est le chef de la division des troubles du mouvement au Massachusetts General Hospital (MGH) et professeur de neurologie \u00e0 la Harvard Medical School. Avant de rejoindre le MGH en 2020, le Dr. Blackstone a pass\u00e9 20 ans aux National Institutes of Health, occupant finalement le poste de chercheur principal et chef de la section de biologie cellulaire au sein de la branche de neurog\u00e9n\u00e9tique. Sous sa direction, son groupe a \u00e9tudi\u00e9 les m\u00e9canismes cellulaires et mol\u00e9culaires des troubles du mouvement h\u00e9r\u00e9ditaires. Il est l\u2019un des principaux chercheurs mondiaux dans ce domaine.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Joseph_Avellone)\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Dr. Joseph Avellone<\/strong><\/a>, chirurgien retrait\u00e9 et cadre de sant\u00e9, a un petit-fils, Carter, qui souffre de SPG3A complexe de novo. Avec d\u2019autres membres de la famille, il a fond\u00e9 la <strong>Fondation Carter pour la recherche neurologique<\/strong>.<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-early-onset-hsp-natural-history-study\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-early-onset-hsp-natural-history-study\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-early-onset-hsp-natural-history-study-button\" aria-expanded=\"false\" aria-controls=\"accordion-early-onset-hsp-natural-history-study-content\">\n          <span class=\"ghostkit-accordion-item-label\">\u00c9tude sur l\u2019histoire naturelle de la PSH \u00e0 d\u00e9but pr\u00e9coce<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-early-onset-hsp-natural-history-study-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-early-onset-hsp-natural-history-study-button\">\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/connects.catalyst.harvard.edu\/Profiles\/display\/Person\/125033\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Dr. Darius Ebrahimi-Fakhari<\/strong><\/a> de <a href=\"https:\/\/www.childrenshospital.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>l\u2019H\u00f4pital pour enfants de Boston<\/strong><\/a> construit <a href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>un registre de toutes les parapl\u00e9gies spastiques h\u00e9r\u00e9ditaires \u00e0 d\u00e9but p\u00e9diatrique<\/strong><\/a> (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04712812?cond=NCT47_12812&#038;draw=2&#038;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\">Registre et \u00e9tude sur l\u2019histoire naturelle de la parapl\u00e9gie spastique h\u00e9r\u00e9ditaire \u00e0 d\u00e9but pr\u00e9coce<\/a>).<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Les \u00e9tudes sur l\u2019histoire naturelle sont cruciales pour les maladies rares. Sans elles, les options de traitement ne seront pas disponibles. Les futurs essais cliniques li\u00e9s aux traitements de la PSH p\u00e9diatrique, y compris ceux qui pourraient d\u00e9couler du programme de recherche de la Fondation Carter pour la recherche neurologique, d\u00e9pendront probablement de ce registre.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><strong>L\u2019\u00e9tude recherche encore des participants \u00e0 l\u2019\u00e9chelle mondiale.<\/strong> En ao\u00fbt 2022, <a href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>le registre ne comptait que 11 cas de SPG3A<\/strong>.<\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Si vous avez SPG3A et que vous n\u2019\u00eates pas encore inscrit, nous vous recommandons vivement de contacter <br><a href=\"http:\/\/sahin-lab.org\/people\/catherine-jordan-ms\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Amy Tam<\/strong><\/a>, la coordinatrice de l\u2019\u00e9tude, par e-mail : <br><a href=\"http:\/\/Catherine.Jordan@childrens.harvard.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>amy.tam@childrens.harvard.edu<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>La participation est GRATUITE et comprend une consultation d\u2019une heure par Zoom avec le Dr. Darius.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Crit\u00e8res d\u2019inclusion :<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:list -->\n        <ul class=\"wp-block-list\">\n          <!-- wp:list-item -->\n          <li>Apparition des sympt\u00f4mes de la parapl\u00e9gie spastique h\u00e9r\u00e9ditaire avant l\u2019\u00e2ge de 18 ans<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>\u00c2ge actuel inf\u00e9rieur \u00e0 30 ans<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>Pr\u00e9sence de variantes dans les g\u00e8nes li\u00e9s \u00e0 la PSH et\/ou un proche avec un tel diagnostic<\/li>\n          <!-- \/wp:list-item -->\n        <\/ul>\n        <!-- \/\n\nwp:list -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:list -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\" aria-expanded=\"false\" aria-controls=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\">\n          <span class=\"ghostkit-accordion-item-label\">Conclusions pour SPG3A tir\u00e9es du symposium sur SPG4 de novo organis\u00e9 par les NIH<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\">\n        <!-- wp:paragraph -->\n        <p>Le Dr. Craig Blackstone du Massachusetts General Hospital \u00e0 Boston est l\u2019un des principaux chercheurs sur la PSH, en particulier sur SPG3A.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>En collaboration avec la Fondation Carter pour la recherche sur les maladies neurologiques, il teste, \u00e0 la fois sur des mod\u00e8les in vitro et in vivo, divers compos\u00e9s pharmacologiques et m\u00e9thodes de th\u00e9rapie g\u00e9nique dans le but de concevoir des essais cliniques pour les enfants atteints de SPG3A de novo dans un avenir proche.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Vous pouvez regarder la pr\u00e9sentation de la recherche du Dr. Blackstone ici, \u00e0 partir de la minute 24:32 : <a href=\"https:\/\/videocast.nih.gov\/watch=44694\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/videocast.nih.gov\/watch=44694<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Voici un extrait de sa pr\u00e9sentation :<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Le Dr. Blackstone et la Fondation Carter s\u2019appuieront sur l\u2019\u00e9tude sur l\u2019histoire naturelle de la PSH de l\u2019H\u00f4pital pour enfants de Boston (d\u00e9crite ci-dessus) pour concevoir tout futur essai clinique.<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-mutational-cluster-causing-more-severe-spg3a\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-mutational-cluster-causing-more-severe-spg3a\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\" aria-expanded=\"false\" aria-controls=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\">\n          <span class=\"ghostkit-accordion-item-label\">Groupe de mutations causant une SPG3A plus s\u00e9v\u00e8re<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\">\n        <!-- wp:paragraph -->\n        <p>Les chercheurs Julian E. Alecu, Afshin Saffari, Catherine Jordan, Siddharth Srivastava, Craig Blackstone et Darius Ebrahimi-Fakhari ont effectu\u00e9 une analyse transversale de 537 patients atteints de SPG3A, dont 31 pr\u00e9sentaient des variantes de novo d\u2019ATL1.<br><br>Ils ont identifi\u00e9 que certaines variantes, situ\u00e9es dans un groupe de mutations tridimensionnel, entra\u00eenent des sympt\u00f4mes plus graves qui vont au-del\u00e0 de la PSH pure affectant uniquement les membres inf\u00e9rieurs. Les sympt\u00f4mes plus complexes incluent des anomalies neurod\u00e9veloppementales, une spasticit\u00e9 des membres sup\u00e9rieurs, des sympt\u00f4mes bulbaires (dysarthrie, dysphagie, etc.), une neuropathie p\u00e9riph\u00e9rique et des anomalies \u00e0 l\u2019imagerie c\u00e9r\u00e9brale.<br><br>Les variantes identifi\u00e9es dans ce groupe sont : <strong>Ala350, Arg403, Arg415, Arg416, Asn355, Gly409, Gly410, Leu401, Lys407, Met347, Met408, Phe413, Pro344, Ser346, Ser398, Ser414, Tyr417, Val405<\/strong>.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Leurs d\u00e9couvertes \u00e9tablissent une relation g\u00e9notype-ph\u00e9notype pour les mutations d\u2019ATL1. Ce groupe de mutations guidera les options de traitement futures.<br><strong>\u200d<\/strong><br>Vous pouvez lire le r\u00e9sum\u00e9 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35925862\/\" target=\"_blank\" rel=\"noreferrer noopener\">ici<\/a>.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:image {\"id\":151,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n        <figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1355\" height=\"913\" src=\"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18.png\" alt=\"\" class=\"wp-image-151\" title=\"\" srcset=\"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18.png 1355w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-300x202.png 300w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-1024x690.png 1024w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-768x517.png 768w\" sizes=\"auto, (max-width: 1355px) 100vw, 1355px\" \/><\/figure>\n        <!-- \/wp:image -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n  <\/div>\n  <!-- \/wp:ghostkit\/accordion-item -->\n<\/div>\n<!-- \/wp:ghostkit\/accordion --><!-- \/wp:group -->","protected":false},"excerpt":{"rendered":"<p>Recherche Le programme de recherche de la Fondation Carter La mission de la Fondation Carter est de permettre le d\u00e9veloppement de th\u00e9rapies et de traitements pour les enfants atteints de parapl\u00e9gie spastique h\u00e9r\u00e9ditaire (PSH). Elle se concentre actuellement sur les deux formes les plus courantes de PSH, SPG3A et SPG4, avec un accent particulier sur [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ghostkit_customizer_options":"","ghostkit_custom_css":"","ghostkit_custom_js_head":"","ghostkit_custom_js_foot":"","ghostkit_typography":"","footnotes":""},"class_list":["post-150","page","type-page","status-publish","hentry"],"blocksy_meta":{"background":{"background_type":"image","background_pattern":"type-1","background_image":{"attachment_id":154,"x":0,"y":0,"url":"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f4a6c6c5db63aa2f18407_Layer-0-1-613x1024.png"},"gradient":"linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%)","background_repeat":"repeat","background_size":"cover","background_attachment":"scroll","patternColor":{"default":{"color":"#e5e7ea"}},"overlayColor":{"default":{"color":"CT_CSS_SKIP_RULE"}},"backgroundColor":{"default":{"color":"#ffffff"}}},"styles_descriptor":{"styles":{"desktop":"[data-prefix=\"single_page\"] {background-position:0% 0%;background-size:cover;background-color:#ffffff;background-image:url(https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f4a6c6c5db63aa2f18407_Layer-0-1-scaled.png);}","tablet":"","mobile":""},"google_fonts":[],"version":6},"has_hero_section":"disabled"},"_links":{"self":[{"href":"https:\/\/kidswithspg3a.com\/fr\/wp-json\/wp\/v2\/pages\/150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidswithspg3a.com\/fr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kidswithspg3a.com\/fr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kidswithspg3a.com\/fr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidswithspg3a.com\/fr\/wp-json\/wp\/v2\/comments?post=150"}],"version-history":[{"count":16,"href":"https:\/\/kidswithspg3a.com\/fr\/wp-json\/wp\/v2\/pages\/150\/revisions"}],"predecessor-version":[{"id":213,"href":"https:\/\/kidswithspg3a.com\/fr\/wp-json\/wp\/v2\/pages\/150\/revisions\/213"}],"wp:attachment":[{"href":"https:\/\/kidswithspg3a.com\/fr\/wp-json\/wp\/v2\/media?parent=150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}