{"id":150,"date":"2025-04-28T17:51:29","date_gmt":"2025-04-28T17:51:29","guid":{"rendered":"https:\/\/honeydew-hyena-350809.hostingersite.com\/?page_id=150"},"modified":"2025-05-08T12:59:25","modified_gmt":"2025-05-08T12:59:25","slug":"research","status":"publish","type":"page","link":"https:\/\/kidswithspg3a.com\/hi\/research\/","title":{"rendered":"\u0905\u0928\u0941\u0938\u0902\u0927\u093e\u0928"},"content":{"rendered":"<!-- wp:spacer -->\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:group {\"style\":{\"color\":{\"background\":\"#ffffff91\"}},\"layout\":{\"type\":\"constrained\"}} -->\n<div class=\"wp-block-group has-background\" style=\"background-color:#ffffff91\">\n  <!-- wp:heading {\"level\":1} -->\n  <h1 class=\"wp-block-heading\" id=\"research\">\u0905\u0928\u0941\u0938\u0902\u0927\u093e\u0928<\/h1>\n  <!-- \/wp:heading -->\n\n  <!-- wp:ghostkit\/accordion 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class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-the-carter-foundation-research-program-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-the-carter-foundation-research-program-button\">\n        <!-- wp:embed {\"url\":\"https:\/\/www.youtube.com\/watch?v=LNd_Oog5fiU\",\"type\":\"video\",\"providerNameSlug\":\"youtube\",\"responsive\":true,\"className\":\"wp-embed-aspect-16-9 wp-has-aspect-ratio\"} -->\n        <figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\">\n          <div class=\"wp-block-embed__wrapper\">\n            <iframe loading=\"lazy\" title=\"Carter Foundation SPG3A Research Program Update - February 2025\" width=\"1290\" height=\"726\" src=\"https:\/\/www.youtube.com\/embed\/LNd_Oog5fiU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n          <\/div>\n        <\/figure>\n        <!-- \/wp:embed -->\n\n        <!-- wp:paragraph -->\n        <p><strong>\u0915\u093e\u0930\u094d\u091f\u0930 \u092b\u093e\u0909\u0902\u0921\u0947\u0936\u0928<\/strong> \u0915\u093e \u092e\u093f\u0936\u0928 \u0935\u0902\u0936\u093e\u0928\u0941\u0917\u0924 \u0938\u094d\u092a\u093e\u0938\u094d\u091f\u093f\u0915 \u092a\u0948\u0930\u093e\u092a\u094d\u0932\u0947\u091c\u093f\u092f\u093e (HSP) \u0938\u0947 \u092a\u0940\u0921\u093c\u093f\u0924 \u092c\u091a\u094d\u091a\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u0909\u092a\u091a\u093e\u0930 \u0914\u0930 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u0935\u093f\u0915\u093e\u0938 \u0915\u094b \u0938\u0915\u094d\u0937\u092e \u0915\u0930\u0928\u093e \u0939\u0948\u0964 \u0935\u0930\u094d\u0924\u092e\u093e\u0928 \u092e\u0947\u0902 \u092f\u0939 HSP \u0915\u0947 \u0926\u094b \u0938\u092c\u0938\u0947 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0930\u0942\u092a\u094b\u0902, SPG3A \u0914\u0930 SPG4 \u092a\u0930 \u0915\u0947\u0902\u0926\u094d\u0930\u093f\u0924 \u0939\u0948, \u0935\u093f\u0936\u0947\u0937 \u0930\u0942\u092a \u0938\u0947 \u0909\u0928 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928\u094b\u0902 \u092a\u0930 \u091c\u094b \u091c\u0932\u094d\u0926\u0940 \u0936\u0941\u0930\u0942 \u0939\u094b\u0924\u0947 \u0939\u0948\u0902 \u0914\u0930 \u0905\u0915\u094d\u0938\u0930 \u0921\u0940 \u0928\u094b\u0935\u094b (de novo) \u0938\u094d\u0925\u093f\u0924\u093f\u092f\u094b\u0902 \u0915\u0947 \u0938\u093e\u0925 \u0939\u094b\u0924\u0947 \u0939\u0948\u0902\u0964<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u092b\u093e\u0909\u0902\u0921\u0947\u0936\u0928 \u0915\u093e \u092a\u094d\u0930\u092f\u093e\u0938 \u0907\u0928 \u0938\u094d\u0925\u093f\u0924\u093f\u092f\u094b\u0902 \u0915\u0940 \u092c\u0941\u0928\u093f\u092f\u093e\u0926\u0940 \u0938\u0947\u0932\u0941\u0932\u0930 \u0914\u0930 \u091c\u0947\u0928\u0947\u091f\u093f\u0915 \u0938\u092e\u091d \u0914\u0930 \u0909\u092a\u091a\u093e\u0930 \u0915\u0947 \u0935\u093f\u0915\u093e\u0938 \u0915\u0947 \u092c\u0940\u091a \u0915\u0940 \u0916\u093e\u0908 \u0915\u094b \u092a\u093e\u091f\u0928\u093e \u0939\u0948\u0964 \u0907\u0938\u0947 \u091f\u094d\u0930\u093e\u0902\u0938\u0932\u0947\u0936\u0928\u0932 \u092e\u0947\u0921\u093f\u0938\u093f\u0928 \u0915\u0939\u093e \u091c\u093e\u0924\u093e \u0939\u0948\u0964 \u0907\u0938\u0915\u093e \u092e\u0924\u0932\u092c \u0939\u0948 \u0915\u093f \u0907\u0928 \u0938\u094d\u0925\u093f\u0924\u093f\u092f\u094b\u0902 \u0915\u0940 \u0935\u0930\u094d\u0924\u092e\u093e\u0928 \u092c\u0941\u0928\u093f\u092f\u093e\u0926\u0940 \u0935\u0948\u091c\u094d\u091e\u093e\u0928\u093f\u0915 \u0938\u092e\u091d \u0915\u094b \u0932\u0947\u0928\u093e \u0914\u0930 \u091c\u0940\u0935\u093f\u0924 \u092a\u0936\u0941 \u092e\u0949\u0921\u0932 \u092e\u0947\u0902 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u0940\u092f \u092a\u0930\u093f\u0915\u0932\u094d\u092a\u0928\u093e\u0913\u0902 \u0915\u094b \u0938\u093e\u092c\u093f\u0924 \u0915\u0930\u0928\u093e\u0964 \u090f\u0915 \u092a\u0941\u0928\u0930\u0941\u0924\u094d\u092a\u093e\u0926\u0928 \u092f\u094b\u0917\u094d\u092f \u092a\u0936\u0941 \u092e\u0949\u0921\u0932 \u0915\u0947 \u0938\u093e\u0925, \u092c\u093e\u092f\u094b\u092b\u093e\u0930\u094d\u092e\u093e\u0938\u094d\u092f\u0941\u091f\u093f\u0915\u0932 \u0915\u0902\u092a\u0928\u093f\u092f\u093e\u0902 \u0914\u0930 \u0938\u0902\u0938\u094d\u0925\u093e\u0928 \u0914\u092a\u091a\u093e\u0930\u093f\u0915 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u0940\u092f \u0935\u093f\u0915\u093e\u0938 \u0914\u0930 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0936\u0941\u0930\u0942 \u0915\u0930 \u0938\u0915\u0924\u0947 \u0939\u0948\u0902\u0964<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u0907\u0938 \u0935\u0940\u0921\u093f\u092f\u094b \u092e\u0947\u0902, \u0921\u0949. \u092c\u094d\u0932\u0948\u0915\u0938\u094d\u091f\u094b\u0928 \u0914\u0930 \u0921\u0949. \u090f\u0935\u0947\u0932\u094b\u0928 <strong>\u0915\u093e\u0930\u094d\u091f\u0930 \u092b\u093e\u0909\u0902\u0921\u0947\u0936\u0928 \u0905\u0928\u0941\u0938\u0902\u0927\u093e\u0928 \u0915\u093e\u0930\u094d\u092f\u0915\u094d\u0930\u092e \u0915\u0947 \u0928\u0935\u0940\u0928\u0924\u092e \u0935\u093f\u0915\u093e\u0938<\/strong> \u092a\u0930 \u091a\u0930\u094d\u091a\u093e \u0915\u0930\u0924\u0947 \u0939\u0948\u0902, \u091c\u094b \u091c\u0948\u0915\u094d\u0938\u0928 \u0932\u0948\u092c\u094b\u0930\u0947\u091f\u0930\u0940\u091c \u092e\u0947\u0902 \u0935\u093f\u0915\u0938\u093f\u0924 SPG3A \u092e\u093e\u0909\u0938 \u092e\u0949\u0921\u0932 \u092e\u0947\u0902 \u0928\u093f\u092e\u094d\u0928\u0932\u093f\u0916\u093f\u0924 \u091a\u093e\u0930 \u091a\u093f\u0915\u093f\u0924\u094d\u0938\u0940\u092f \u092a\u0930\u093f\u0915\u0932\u094d\u092a\u0928\u093e\u0913\u0902 \u0915\u093e \u0905\u0927\u094d\u092f\u092f\u0928 \u0915\u0930 \u0930\u0939\u093e \u0939\u0948:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>&#8211; \u0932\u093f\u092a\u093f\u0921 \u092e\u0949\u0921\u094d\u092f\u0942\u0932\u0947\u0936\u0928 \u090f\u091c\u0947\u0902\u091f<br>&#8211; \u092c\u094b\u0928 \u092e\u0949\u0930\u094d\u092b\u094b\u091c\u0947\u0928\u093f\u0915 \u092a\u094d\u0930\u094b\u091f\u0940\u0928 (BMP) \u0938\u093f\u0917\u094d\u0928\u0932\u093f\u0902\u0917 \u092a\u093e\u0925\u0935\u0947 \u0915\u093e \u0905\u0935\u0930\u094b\u0927\u0928<br>&#8211; \u090f\u0902\u091f\u0940\u0938\u0947\u0928\u094d\u0938 \u0911\u0932\u093f\u0917\u094b\u0928\u094d\u092f\u0942\u0915\u094d\u0932\u093f\u092f\u094b\u091f\u093e\u0907\u0921 (ASO) \u0925\u0947\u0930\u0947\u092a\u0940<br>&#8211; \u0909\u0928\u094d\u0928\u0924 \u091c\u0940\u0928 \u090f\u0921\u093f\u091f\u093f\u0902\u0917 (\u092c\u0947\u0938 \u090f\u0921\u093f\u091f\u093f\u0902\u0917)<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u0905\u0928\u0941\u092e\u093e\u0928\u093f\u0924 \u0938\u092e\u092f\u0938\u0940\u092e\u093e: 1-2 \u0935\u0930\u094d\u0937\u0964 \u0939\u093e\u0932\u093e\u0902\u0915\u093f, \u091c\u0948\u0938\u0947 \u0939\u0940 \u0915\u094b\u0908 \u092d\u0940 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\u092c\u094d\u0932\u0948\u0915\u0938\u094d\u091f\u094b\u0928<\/strong><\/a> \u092e\u0948\u0938\u093e\u091a\u0941\u0938\u0947\u091f\u094d\u0938 \u091c\u0928\u0930\u0932 \u0939\u0949\u0938\u094d\u092a\u093f\u091f\u0932 (MGH) \u092e\u0947\u0902 \u092e\u0942\u0935\u092e\u0947\u0902\u091f \u0921\u093f\u0938\u0911\u0930\u094d\u0921\u0930 \u0921\u093f\u0935\u0940\u091c\u0928 \u0915\u0947 \u092a\u094d\u0930\u092e\u0941\u0916 \u0914\u0930 \u0939\u093e\u0930\u094d\u0935\u0930\u094d\u0921 \u092e\u0947\u0921\u093f\u0915\u0932 \u0938\u094d\u0915\u0942\u0932 \u092e\u0947\u0902 \u0928\u094d\u092f\u0942\u0930\u094b\u0932\u0949\u091c\u0940 \u0915\u0947 \u092a\u094d\u0930\u094b\u092b\u0947\u0938\u0930 \u0939\u0948\u0902\u0964 2020 \u092e\u0947\u0902 MGH \u092e\u0947\u0902 \u0906\u0928\u0947 \u0938\u0947 \u092a\u0939\u0932\u0947, \u0921\u0949. \u092c\u094d\u0932\u0948\u0915\u0938\u094d\u091f\u094b\u0928 \u0928\u0947 \u0928\u0947\u0936\u0928\u0932 \u0907\u0902\u0938\u094d\u091f\u0940\u091f\u094d\u092f\u0942\u091f\u094d\u0938 \u0911\u092b \u0939\u0947\u0932\u094d\u0925 \u092e\u0947\u0902 20 \u0938\u093e\u0932 \u092c\u093f\u0924\u093e\u090f, \u0905\u0902\u0924\u0924\u0903 \u0928\u094d\u092f\u0942\u0930\u094b\u091c\u0947\u0928\u0947\u091f\u093f\u0915\u094d\u0938 \u0936\u093e\u0916\u093e \u0915\u0947 \u092d\u0940\u0924\u0930 \u0938\u0940\u0928\u093f\u092f\u0930 \u0907\u0928\u094d\u0935\u0947\u0938\u094d\u091f\u093f\u0917\u0947\u091f\u0930 \u0914\u0930 \u0938\u0947\u0932 \u092c\u093e\u092f\u094b\u0932\u0949\u091c\u0940 \u0938\u0947\u0915\u094d\u0936\u0928 \u091a\u0940\u092b \u0915\u0947 \u0930\u0942\u092a \u092e\u0947\u0902\u0964 \u0909\u0928\u0915\u0947 \u0928\u0947\u0924\u0943\u0924\u094d\u0935 \u092e\u0947\u0902, \u0909\u0928\u0915\u0947 \u0938\u092e\u0942\u0939 \u0928\u0947 \u0935\u0902\u0936\u093e\u0928\u0941\u0917\u0924 \u092e\u0942\u0935\u092e\u0947\u0902\u091f \u0921\u093f\u0938\u0911\u0930\u094d\u0921\u0930 \u0915\u0947 \u0938\u0947\u0932\u0941\u0932\u0930 \u0914\u0930 \u0906\u0923\u0935\u093f\u0915 \u0924\u0902\u0924\u094d\u0930\u094b\u0902 \u0915\u0940 \u091c\u093e\u0902\u091a \u0915\u0940\u0964 \u0935\u0947 \u0907\u0938 \u0915\u094d\u0937\u0947\u0924\u094d\u0930 \u092e\u0947\u0902 \u0926\u0941\u0928\u093f\u092f\u093e \u0915\u0947 \u0905\u0917\u094d\u0930\u0923\u0940 \u0905\u0928\u0941\u0938\u0902\u0927\u093e\u0928\u0915\u0930\u094d\u0924\u093e\u0913\u0902 \u092e\u0947\u0902 \u0938\u0947 \u090f\u0915 \u0939\u0948\u0902\u0964<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Joseph_Avellone)\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\u0921\u0949. \u091c\u094b\u0938\u0947\u092b \u090f\u0935\u0947\u0932\u094b\u0928<\/strong><\/a>, \u090f\u0915 \u0938\u0947\u0935\u093e\u0928\u093f\u0935\u0943\u0924\u094d\u0924 \u0938\u0930\u094d\u091c\u0928 \u0914\u0930 \u0938\u094d\u0935\u093e\u0938\u094d\u0925\u094d\u092f \u0915\u093e\u0930\u094d\u092f\u0915\u093e\u0930\u0940, \u0915\u0947 \u092a\u093e\u0938 \u090f\u0915 \u092a\u094b\u0924\u093e, \u0915\u093e\u0930\u094d\u091f\u0930, \u0939\u0948 \u091c\u094b \u0921\u0940 \u0928\u094b\u0935\u094b \u091c\u091f\u093f\u0932 SPG3A \u0938\u0947 \u092a\u0940\u0921\u093c\u093f\u0924 \u0939\u0948\u0964 \u0909\u0928\u094d\u0939\u094b\u0902\u0928\u0947 \u0905\u0928\u094d\u092f \u092a\u0930\u093f\u0935\u093e\u0930 \u0915\u0947 \u0938\u0926\u0938\u094d\u092f\u094b\u0902 \u0915\u0947 \u0938\u093e\u0925 \u092e\u093f\u0932\u0915\u0930 <strong>\u0915\u093e\u0930\u094d\u091f\u0930 \u0928\u094d\u092f\u0942\u0930\u094b\u0932\u0949\u091c\u093f\u0915\u0932 \u0930\u093f\u0938\u0930\u094d\u091a \u092b\u093e\u0909\u0902\u0921\u0947\u0936\u0928<\/strong> \u0915\u0940 \u0938\u094d\u0925\u093e\u092a\u0928\u093e \u0915\u0940\u0964<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-early-onset-hsp-natural-history-study\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-early-onset-hsp-natural-history-study\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-early-onset-hsp-natural-history-study-button\" aria-expanded=\"false\" aria-controls=\"accordion-early-onset-hsp-natural-history-study-content\">\n          <span class=\"ghostkit-accordion-item-label\">\u092a\u094d\u0930\u093e\u0930\u0902\u092d\u093f\u0915 \u0936\u0941\u0930\u0941\u0906\u0924 HSP \u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915 \u0907\u0924\u093f\u0939\u093e\u0938 \u0905\u0927\u094d\u092f\u092f\u0928<\/span>\n          <span class=\"ghostkit-acord-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-early-onset-hsp-natural-history-study-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-early-onset-hsp-natural-history-study-button\">\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/connects.catalyst.harvard.edu\/Profiles\/display\/Person\/125033\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\u0921\u0949. \u0926\u093e\u0930\u093f\u092f\u0938 \u090f\u092c\u094d\u0930\u093e\u0939\u093f\u092e\u0940-\u092b\u0916\u093e\u0930\u0940<\/strong><\/a> <a href=\"https:\/\/www.childrenshospital.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\u092c\u094b\u0938\u094d\u091f\u0928 \u091a\u093f\u0932\u094d\u0921\u094d\u0930\u0928\u094d\u0938 \u0939\u0949\u0938\u094d\u092a\u093f\u091f\u0932<\/strong><\/a> \u0938\u0947, <a href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>\u092c\u091a\u092a\u0928 \u092e\u0947\u0902 \u0936\u0941\u0930\u0942 \u0939\u094b\u0928\u0947 \u0935\u093e\u0932\u0940 \u0938\u092d\u0940 \u0935\u0902\u0936\u093e\u0928\u0941\u0917\u0924 \u0938\u094d\u092a\u093e\u0938\u094d\u091f\u093f\u0915 \u092a\u0948\u0930\u093e\u092a\u094d\u0932\u0947\u091c\u093f\u092f\u093e \u0915\u093e \u0930\u091c\u093f\u0938\u094d\u091f\u094d\u0930\u0940<\/strong><\/a> \u092c\u0928\u093e \u0930\u0939\u0947 \u0939\u0948\u0902 (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT47_12812?cond=NCT47_12812&#038;draw=2&#038;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\">\u092a\u094d\u0930\u093e\u0930\u0902\u092d\u093f\u0915 \u0936\u0941\u0930\u0941\u0906\u0924 \u0935\u0902\u0936\u093e\u0928\u0941\u0917\u0924 \u0938\u094d\u092a\u093e\u0938\u094d\u091f\u093f\u0915 \u092a\u0948\u0930\u093e\u092a\u094d\u0932\u0947\u091c\u093f\u092f\u093e \u0915\u0947 \u0932\u093f\u090f \u0930\u091c\u093f\u0938\u094d\u091f\u094d\u0930\u0940 \u0914\u0930 \u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915 \u0907\u0924\u093f\u0939\u093e\u0938 \u0905\u0927\u094d\u092f\u092f\u0928<\/a>)\u0964<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915 \u0907\u0924\u093f\u0939\u093e\u0938 \u0905\u0927\u094d\u092f\u092f\u0928 \u0926\u0941\u0930\u094d\u0932\u092d \u092c\u0940\u092e\u093e\u0930\u093f\u092f\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u092e\u0939\u0924\u094d\u0935\u092a\u0942\u0930\u094d\u0923 \u0939\u0948\u0902\u0964 \u0909\u0928\u0915\u0947 \u092c\u093f\u0928\u093e, \u0909\u092a\u091a\u093e\u0930 \u0935\u093f\u0915\u0932\u094d\u092a \u0909\u092a\u0932\u092c\u094d\u0927 \u0928\u0939\u0940\u0902 \u0939\u094b\u0902\u0917\u0947\u0964 \u092c\u091a\u094d\u091a\u094b\u0902 \u092e\u0947\u0902 HSP \u0915\u0947 \u0932\u093f\u090f \u0907\u0932\u093e\u091c \u0938\u0947 \u0938\u0902\u092c\u0902\u0927\u093f\u0924 \u092d\u0935\u093f\u0937\u094d\u092f \u0915\u0947 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923, \u091c\u093f\u0938\u092e\u0947\u0902 \u0915\u093e\u0930\u094d\u091f\u0930 \u0928\u094d\u092f\u0942\u0930\u094b\u0932\u0949\u091c\u093f\u0915\u0932 \u0930\u093f\u0938\u0930\u094d\u091a \u092b\u093e\u0909\u0902\u0921\u0947\u0936\u0928 \u0915\u0947 \u0905\u0928\u0941\u0938\u0902\u0927\u093e\u0928 \u0915\u093e\u0930\u094d\u092f\u0915\u094d\u0930\u092e \u0938\u0947 \u0909\u0924\u094d\u092a\u0928\u094d\u0928 \u0939\u094b\u0928\u0947 \u0935\u093e\u0932\u0947 \u0936\u093e\u092e\u093f\u0932 \u0939\u094b \u0938\u0915\u0924\u0947 \u0939\u0948\u0902, \u0938\u0902\u092d\u0935\u0924\u0903 \u0907\u0938 \u0930\u091c\u093f\u0938\u094d\u091f\u094d\u0930\u0940 \u092a\u0930 \u0928\u093f\u0930\u094d\u092d\u0930 \u0915\u0930\u0947\u0902\u0917\u0947\u0964<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><strong>\u092f\u0939 \u0905\u0927\u094d\u092f\u092f\u0928 \u0905\u092d\u0940 \u092d\u0940 \u0935\u0948\u0936\u094d\u0935\u093f\u0915 \u0938\u094d\u0924\u0930 \u092a\u0930 \u092a\u094d\u0930\u0924\u093f\u092d\u093e\u0917\u093f\u092f\u094b\u0902 \u0915\u0940 \u0924\u0932\u093e\u0936 \u092e\u0947\u0902 \u0939\u0948\u0964<\/strong> \u0905\u0917\u0938\u094d\u0924 2022 \u0924\u0915, <a href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>\u0930\u091c\u093f\u0938\u094d\u091f\u094d\u0930\u0940 \u092e\u0947\u0902 \u0915\u0947\u0935\u0932 11 SPG3A \u092e\u093e\u092e\u0932\u0947<\/strong> \u0925\u0947\u0964<\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u092f\u0926\u093f \u0906\u092a\u0915\u0947 \u092a\u093e\u0938 SPG3A \u0939\u0948 \u0914\u0930 \u0906\u092a\u0928\u0947 \u0905\u092d\u0940 \u0924\u0915 \u092a\u0902\u091c\u0940\u0915\u0930\u0923 \u0928\u0939\u0940\u0902 \u0915\u093f\u092f\u093e \u0939\u0948, \u0924\u094b \u0939\u092e \u0926\u0943\u0922\u093c\u0924\u093e \u0938\u0947 \u0938\u0932\u093e\u0939 \u0926\u0947\u0924\u0947 \u0939\u0948\u0902 \u0915\u093f \u0906\u092a \u0905\u0927\u094d\u092f\u092f\u0928 \u0938\u092e\u0928\u094d\u0935\u092f\u0915 <br><a href=\"http:\/\/sahin-lab.org\/people\/catherine-jordan-ms\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\u090f\u092e\u0940 \u091f\u0948\u092e<\/strong><\/a> \u0938\u0947 \u0909\u0928\u0915\u0947 \u0908\u092e\u0947\u0932 \u092a\u0930 \u0938\u0902\u092a\u0930\u094d\u0915 \u0915\u0930\u0947\u0902: <br><a href=\"http:\/\/Catherine.Jordan@childrens.harvard.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>amy.tam@childrens.harvard.edu<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u092d\u093e\u0917\u0940\u0926\u093e\u0930\u0940 \u092e\u0941\u092b\u094d\u0924 \u0939\u0948 \u0914\u0930 \u0907\u0938\u092e\u0947\u0902 \u0921\u0949. \u0926\u093e\u0930\u093f\u092f\u0938 \u0915\u0947 \u0938\u093e\u0925 1 \u0918\u0902\u091f\u0947 \u0915\u0940 \u091c\u093c\u0942\u092e \u092a\u0930\u093e\u092e\u0930\u094d\u0936 \u0936\u093e\u092e\u093f\u0932 \u0939\u0948\u0964<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u0938\u092e\u093e\u0935\u0947\u0936\u0928 \u092e\u093e\u0928\u0926\u0902\u0921:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:list -->\n        <ul class=\"wp-block-list\">\n          <!-- wp:list-item -->\n          <li>\u0935\u0902\u0936\u093e\u0928\u0941\u0917\u0924 \u0938\u094d\u092a\u093e\u0938\u094d\u091f\u093f\u0915 \u092a\u0948\u0930\u093e\u092a\u094d\u0932\u0947\u091c\u093f\u092f\u093e \u0915\u0947 \u0932\u0915\u094d\u0937\u0923\u094b\u0902 \u0915\u093e 18 \u0935\u0930\u094d\u0937 \u0915\u0940 \u0906\u092f\u0941 \u0938\u0947 \u092a\u0939\u0932\u0947 \u0936\u0941\u0930\u0942 \u0939\u094b\u0928\u093e<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>\u0935\u0930\u094d\u0924\u092e\u093e\u0928 \u0906\u092f\u0941 30 \u0935\u0930\u094d\u0937 \u0938\u0947 \u0915\u092e<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>HSP \u0938\u0947 \u0938\u0902\u092c\u0902\u0927\u093f\u0924 \u091c\u0940\u0928\u094b\u0902 \u092e\u0947\u0902 \u0935\u0947\u0930\u093f\u090f\u0902\u091f \u0939\u094b\u0928\u093e \u0914\u0930\/\u092f\u093e \u0910\u0938\u0947 \u0928\u093f\u0926\u093e\u0928 \u0915\u0947 \u0938\u093e\u0925 \u0915\u094b\u0908 \u0930\u093f\u0936\u094d\u0924\u0947\u0926\u093e\u0930 \u0939\u094b\u0928\u093e<\/li>\n          <!-- \/wp:list-item -->\n        <\/ul>\n        <!-- \/wp:list -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\" aria-expanded=\"false\" aria-controls=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\">\n          <span class=\"ghostkit-accordion-item-label\">NIH \u0926\u094d\u0935\u093e\u0930\u093e \u0906\u092f\u094b\u091c\u093f\u0924 \u0921\u0940 \u0928\u094b\u0935\u094b SPG4 \u0938\u0902\u0917\u094b\u0937\u094d\u0920\u0940 \u0938\u0947 SPG3A \u0915\u0947 \u0932\u093f\u090f \u0928\u093f\u0937\u094d\u0915\u0930\u094d\u0937<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\">\n        <!-- wp:paragraph -->\n        <p>\u092c\u094b\u0938\u094d\u091f\u0928 \u0915\u0947 \u092e\u0948\u0938\u093e\u091a\u0941\u0938\u0947\u091f\u094d\u0938 \u091c\u0928\u0930\u0932 \u0939\u0949\u0938\u094d\u092a\u093f\u091f\u0932 \u0938\u0947 \u0921\u0949. \u0915\u094d\u0930\u0947\u0917 \u092c\u094d\u0932\u0948\u0915\u0938\u094d\u091f\u094b\u0928, HSP, \u0935\u093f\u0936\u0947\u0937 \u0930\u0942\u092a \u0938\u0947 SPG3A \u092e\u0947\u0902 \u0905\u0917\u094d\u0930\u0923\u0940 \u0936\u094b\u0927\u0915\u0930\u094d\u0924\u093e\u0913\u0902 \u092e\u0947\u0902 \u0938\u0947 \u090f\u0915 \u0939\u0948\u0902\u0964<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u0915\u093e\u0930\u094d\u091f\u0930 \u0928\u094d\u092f\u0942\u0930\u094b\u0932\u0949\u091c\u093f\u0915\u0932 \u0921\u093f\u091c\u0940\u091c \u0930\u093f\u0938\u0930\u094d\u091a \u092b\u093e\u0909\u0902\u0921\u0947\u0936\u0928 \u0915\u0947 \u0938\u0939\u092f\u094b\u0917 \u0938\u0947, \u0935\u0947 \u0907\u0928 \u0935\u093f\u091f\u094d\u0930\u094b \u0914\u0930 \u0907\u0928 \u0935\u093f\u0935\u094b \u092e\u0949\u0921\u0932 \u0926\u094b\u0928\u094b\u0902 \u092e\u0947\u0902 \u0935\u093f\u092d\u093f\u0928\u094d\u0928 \u0926\u0935\u093e \u092f\u094c\u0917\u093f\u0915\u094b\u0902 \u0914\u0930 \u091c\u0940\u0928 \u0925\u0947\u0930\u0947\u092a\u0940 \u0935\u093f\u0927\u093f\u092f\u094b\u0902 \u0915\u093e \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0915\u0930 \u0930\u0939\u0947 \u0939\u0948\u0902, \u0924\u093e\u0915\u093f \u0928\u093f\u0915\u091f \u092d\u0935\u093f\u0937\u094d\u092f \u092e\u0947\u0902 \u0921\u0940 \u0928\u094b\u0935\u094b SPG3A \u0935\u093e\u0932\u0947 \u092c\u091a\u094d\u091a\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0921\u093f\u091c\u093e\u0907\u0928 \u0915\u093f\u090f \u091c\u093e \u0938\u0915\u0947\u0902\u0964<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u0906\u092a \u0921\u0949. \u092c\u094d\u0932\u0948\u0915\u0938\u094d\u091f\u094b\u0928 \u0915\u0947 \u0936\u094b\u0927 \u0915\u0940 \u092a\u094d\u0930\u0938\u094d\u0924\u0941\u0924\u093f \u092f\u0939\u093e\u0902 \u0926\u0947\u0916 \u0938\u0915\u0924\u0947 \u0939\u0948\u0902, \u091c\u094b 24 \u092e\u093f\u0928\u091f 32 \u0938\u0947\u0915\u0902\u0921 \u0938\u0947 \u0936\u0941\u0930\u0942 \u0939\u094b\u0924\u0940 \u0939\u0948: <a href=\"https:\/\/videocast.nih.gov\/watch=44694\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/videocast.nih.gov\/watch=44694<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u092f\u0939\u093e\u0902 \u0909\u0928\u0915\u0940 \u092a\u094d\u0930\u0938\u094d\u0924\u0941\u0924\u093f \u0915\u093e \u090f\u0915 \u0938\u094d\u0928\u0948\u092a\u0936\u0949\u091f \u0939\u0948:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u0921\u0949. \u092c\u094d\u0932\u0948\u0915\u0938\u094d\u091f\u094b\u0928 \u0914\u0930 \u0915\u093e\u0930\u094d\u091f\u0930 \u092b\u093e\u0909\u0902\u0921\u0947\u0936\u0928 \u092d\u0935\u093f\u0937\u094d\u092f \u0915\u0947 \u0915\u093f\u0938\u0940 \u092d\u0940 \u0928\u0948\u0926\u093e\u0928\u093f\u0915 \u092a\u0930\u0940\u0915\u094d\u0937\u0923 \u0915\u094b \u0921\u093f\u091c\u093e\u0907\u0928 \u0915\u0930\u0928\u0947 \u0915\u0947 \u0932\u093f\u090f \u0909\u092a\u0930\u094b\u0915\u094d\u0924 \u0935\u0930\u094d\u0923\u093f\u0924 \u092c\u094b\u0938\u094d\u091f\u0928 \u091a\u093f\u0932\u094d\u0921\u094d\u0930\u0928\u094d\u0938 \u0939\u0949\u0938\u094d\u092a\u093f\u091f\u0932 HSP \u092a\u094d\u0930\u093e\u0915\u0943\u0924\u093f\u0915 \u0907\u0924\u093f\u0939\u093e\u0938 \u0905\u0927\u094d\u092f\u092f\u0928 \u092a\u0930 \u0928\u093f\u0930\u094d\u092d\u0930 \u0915\u0930\u0947\u0902\u0917\u0947\u0964<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-mutational-cluster-causing-more-severe-spg3a\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-mutational-cluster-causing-more-severe-spg3a\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\" aria-expanded=\"false\" aria-controls=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\">\n          <span class=\"ghostkit-accordion-item-label\">\u0905\u0927\u093f\u0915 \u0917\u0902\u092d\u0940\u0930 SPG3A \u0915\u093e \u0915\u093e\u0930\u0923 \u092c\u0928\u0928\u0947 \u0935\u093e\u0932\u093e \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0938\u092e\u0942\u0939<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\">\n        <!-- wp:paragraph -->\n        <p>\u0936\u094b\u0927\u0915\u0930\u094d\u0924\u093e\u0913\u0902 \u091c\u0942\u0932\u093f\u092f\u0928 \u0908. \u090f\u0932\u0947\u0915\u0941, \u0905\u092b\u0936\u093f\u0928 \u0938\u093e\u092b\u093e\u0930\u0940, \u0915\u0948\u0925\u0930\u0940\u0928 \u091c\u0949\u0930\u094d\u0921\u0928, \u0938\u093f\u0926\u094d\u0927\u093e\u0930\u094d\u0925 \u0936\u094d\u0930\u0940\u0935\u093e\u0938\u094d\u0924\u0935, \u0915\u094d\u0930\u0947\u0917 \u092c\u094d\u0932\u0948\u0915\u0938\u094d\u091f\u094b\u0928, \u0914\u0930 \u0926\u093e\u0930\u093f\u092f\u0938 \u090f\u092c\u094d\u0930\u093e\u0939\u093f\u092e\u0940-\u092b\u0916\u093e\u0930\u0940 \u0928\u0947 537 SPG3A \u0930\u094b\u0917\u093f\u092f\u094b\u0902 \u0915\u093e \u090f\u0915 \u0915\u094d\u0930\u0949\u0938-\u0938\u0947\u0915\u094d\u0936\u0928\u0932 \u0935\u093f\u0936\u094d\u0932\u0947\u0937\u0923 \u0915\u093f\u092f\u093e, \u091c\u093f\u0928\u092e\u0947\u0902 \u0938\u0947 31 \u092e\u0947\u0902 \u0921\u0940 \u0928\u094b\u0935\u094b ATL1 \u0935\u0947\u0930\u093f\u090f\u0902\u091f \u0925\u0947\u0964<br><br>\u0909\u0928\u094d\u0939\u094b\u0902\u0928\u0947 \u092a\u093e\u092f\u093e \u0915\u093f \u090f\u0915 \u0924\u094d\u0930\u093f-\u0906\u092f\u093e\u092e\u0940 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0938\u092e\u0942\u0939 \u0915\u0947 \u092d\u0940\u0924\u0930 \u0938\u094d\u0925\u093f\u0924 \u0915\u0941\u091b \u0935\u0947\u0930\u093f\u090f\u0902\u091f \u0905\u0927\u093f\u0915 \u0917\u0902\u092d\u0940\u0930 \u0932\u0915\u094d\u0937\u0923\u094b\u0902 \u0915\u093e \u0915\u093e\u0930\u0923 \u092c\u0928\u0924\u0947 \u0939\u0948\u0902 \u091c\u094b \u0915\u0947\u0935\u0932 \u0928\u093f\u091a\u0932\u0947 \u0905\u0902\u0917\u094b\u0902 \u0915\u094b \u092a\u094d\u0930\u092d\u093e\u0935\u093f\u0924 \u0915\u0930\u0928\u0947 \u0935\u093e\u0932\u0947 \u0936\u0941\u0926\u094d\u0927 HSP \u0938\u0947 \u092a\u0930\u0947 \u091c\u093e\u0924\u0947 \u0939\u0948\u0902\u0964 \u0905\u0927\u093f\u0915 \u091c\u091f\u093f\u0932 \u0932\u0915\u094d\u0937\u0923\u094b\u0902 \u092e\u0947\u0902 \u0928\u094d\u092f\u0942\u0930\u094b\u0921\u0947\u0935\u0932\u092a\u092e\u0947\u0902\u091f\u0932 \u0905\u0938\u093e\u092e\u093e\u0928\u094d\u092f\u0924\u093e\u090f\u0902, \u090a\u092a\u0930\u0940 \u0905\u0902\u0917\u094b\u0902 \u0915\u0940 \u0938\u094d\u092a\u093e\u0938\u094d\u091f\u093f\u0938\u093f\u091f\u0940, \u092c\u0932\u094d\u092c\u0930 \u0932\u0915\u094d\u0937\u0923 (\u0921\u093f\u0938\u093e\u0930\u094d\u0925\u094d\u0930\u093f\u092f\u093e, \u0921\u093f\u0938\u094d\u092b\u0947\u091c\u093f\u092f\u093e, \u0906\u0926\u093f), \u092a\u0930\u093f\u0927\u0940\u092f \u0928\u094d\u092f\u0942\u0930\u094b\u092a\u0948\u0925\u0940 \u0914\u0930 \u092e\u0938\u094d\u0924\u093f\u0937\u094d\u0915 \u0907\u092e\u0947\u091c\u093f\u0902\u0917 \u0905\u0938\u093e\u092e\u093e\u0928\u094d\u092f\u0924\u093e\u090f\u0902 \u0936\u093e\u092e\u093f\u0932 \u0939\u0948\u0902\u0964<br><br>\u0907\u0938 \u0938\u092e\u0942\u0939 \u092e\u0947\u0902 \u092a\u0939\u091a\u093e\u0928\u0947 \u0917\u090f \u0935\u0947\u0930\u093f\u090f\u0902\u091f \u0939\u0948\u0902: <strong>Ala350, Arg403, Arg415, Arg416, Asn355, Gly409, Gly410, Leu401, Lys407, Met347, Met408, Phe413, Pro344, Ser346, Ser398, Ser414, Tyr417, Val405<\/strong>\u0964<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u0909\u0928\u0915\u0947 \u0928\u093f\u0937\u094d\u0915\u0930\u094d\u0937 ATL1 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u090f\u0915 \u091c\u0940\u0928\u094b\u091f\u093e\u0907\u092a-\u092b\u0947\u0928\u094b\u091f\u093e\u0907\u092a \u0938\u0902\u092c\u0902\u0927 \u0938\u094d\u0925\u093e\u092a\u093f\u0924 \u0915\u0930\u0924\u0947 \u0939\u0948\u0902\u0964 \u092f\u0939 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928 \u0938\u092e\u0942\u0939 \u092d\u0935\u093f\u0937\u094d\u092f \u0915\u0947 \u0909\u092a\u091a\u093e\u0930 \u0935\u093f\u0915\u0932\u094d\u092a\u094b\u0902 \u0915\u094b \u0938\u0942\u091a\u093f\u0924 \u0915\u0930\u0947\u0917\u093e\u0964<br><strong>\u200d<\/strong><br>\u0906\u092a \u0938\u093e\u0930 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35925862\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u092f\u0939\u093e\u0902<\/a> \u092a\u0922\u093c \u0938\u0915\u0924\u0947 \u0939\u0948\u0902\u0964<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:image {\"id\":151,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n        <figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1355\" height=\"913\" src=\"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18.png\" alt=\"\" class=\"wp-image-151\" title=\"\" srcset=\"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18.png 1355w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-300x202.png 300w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-1024x690.png 1024w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-768x517.png 768w\" sizes=\"auto, (max-width: 1355px) 100vw, 1355px\" \/><\/figure>\n        <!-- \/wp:image -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n  <\/div>\n  <!-- \/wp:ghostkit\/accordion -->\n<\/div>\n<!-- \/wp:group -->","protected":false},"excerpt":{"rendered":"<p>\u0905\u0928\u0941\u0938\u0902\u0927\u093e\u0928 \u0915\u093e\u0930\u094d\u091f\u0930 \u092b\u093e\u0909\u0902\u0921\u0947\u0936\u0928 \u0905\u0928\u0941\u0938\u0902\u0927\u093e\u0928 \u0915\u093e\u0930\u094d\u092f\u0915\u094d\u0930\u092e \u0915\u093e\u0930\u094d\u091f\u0930 \u092b\u093e\u0909\u0902\u0921\u0947\u0936\u0928 \u0915\u093e \u092e\u093f\u0936\u0928 \u0935\u0902\u0936\u093e\u0928\u0941\u0917\u0924 \u0938\u094d\u092a\u093e\u0938\u094d\u091f\u093f\u0915 \u092a\u0948\u0930\u093e\u092a\u094d\u0932\u0947\u091c\u093f\u092f\u093e (HSP) \u0938\u0947 \u092a\u0940\u0921\u093c\u093f\u0924 \u092c\u091a\u094d\u091a\u094b\u0902 \u0915\u0947 \u0932\u093f\u090f \u0909\u092a\u091a\u093e\u0930 \u0914\u0930 \u0925\u0947\u0930\u0947\u092a\u0940 \u0915\u0947 \u0935\u093f\u0915\u093e\u0938 \u0915\u094b \u0938\u0915\u094d\u0937\u092e \u0915\u0930\u0928\u093e \u0939\u0948\u0964 \u0935\u0930\u094d\u0924\u092e\u093e\u0928 \u092e\u0947\u0902 \u092f\u0939 HSP \u0915\u0947 \u0926\u094b \u0938\u092c\u0938\u0947 \u0938\u093e\u092e\u093e\u0928\u094d\u092f \u0930\u0942\u092a\u094b\u0902, SPG3A \u0914\u0930 SPG4 \u092a\u0930 \u0915\u0947\u0902\u0926\u094d\u0930\u093f\u0924 \u0939\u0948, \u0935\u093f\u0936\u0947\u0937 \u0930\u0942\u092a \u0938\u0947 \u0909\u0928 \u0909\u0924\u094d\u092a\u0930\u093f\u0935\u0930\u094d\u0924\u0928\u094b\u0902 \u092a\u0930 \u091c\u094b \u091c\u0932\u094d\u0926\u0940 \u0936\u0941\u0930\u0942 \u0939\u094b\u0924\u0947 \u0939\u0948\u0902 \u0914\u0930 \u0905\u0915\u094d\u0938\u0930 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