{"id":150,"date":"2025-04-28T17:51:29","date_gmt":"2025-04-28T17:51:29","guid":{"rendered":"https:\/\/honeydew-hyena-350809.hostingersite.com\/?page_id=150"},"modified":"2025-05-08T12:59:25","modified_gmt":"2025-05-08T12:59:25","slug":"research","status":"publish","type":"page","link":"https:\/\/kidswithspg3a.com\/ja\/research\/","title":{"rendered":"\u30ea\u30b5\u30fc\u30c1"},"content":{"rendered":"<!-- wp:spacer -->\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:group {\"style\":{\"color\":{\"background\":\"#ffffff91\"}},\"layout\":{\"type\":\"constrained\"}} -->\n<div class=\"wp-block-group has-background\" style=\"background-color:#ffffff91\">\n  <!-- wp:heading {\"level\":1} -->\n  <h1 class=\"wp-block-heading\" id=\"research\">\u7814\u7a76<\/h1>\n  <!-- \/wp:heading -->\n\n  <!-- wp:ghostkit\/accordion {\"itemsCount\":4,\"collapseOne\":true,\"collapseTitleTag\":\"h2\"} -->\n  <div class=\"ghostkit-accordion 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<p><strong>\u30ab\u30fc\u30bf\u30fc\u8ca1\u56e3<\/strong>\u306e\u4f7f\u547d\u306f\u3001\u907a\u4f1d\u6027\u75d9\u6027\u5bfe\u9ebb\u75fa\uff08HSP\uff09\u3092\u6301\u3064\u5b50\u3069\u3082\u305f\u3061\u306e\u305f\u3081\u306e\u6cbb\u7642\u6cd5\u3084\u7642\u6cd5\u306e\u958b\u767a\u3092\u53ef\u80fd\u306b\u3059\u308b\u3053\u3068\u3067\u3059\u3002\u73fe\u5728\u3001HSP\u306e\u6700\u3082\u4e00\u822c\u7684\u306a2\u3064\u306e\u5f62\u614b\u3067\u3042\u308bSPG3A\u3068SPG4\u306b\u7126\u70b9\u3092\u5f53\u3066\u3001\u7279\u306b\u65e9\u671f\u767a\u75c7\u306e\u5909\u7570\u3084\u3057\u3070\u3057\u3070de novo\u306e\u72b6\u614b\u306b\u91cd\u70b9\u3092\u7f6e\u3044\u3066\u3044\u307e\u3059\u3002<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u8ca1\u56e3\u306e\u53d6\u308a\u7d44\u307f\u306f\u3001\u3053\u308c\u3089\u306e\u75be\u60a3\u306e\u57fa\u790e\u7684\u306a\u7d30\u80de\u304a\u3088\u3073\u907a\u4f1d\u7684\u7406\u89e3\u3068\u6cbb\u7642\u6cd5\u306e\u958b\u767a\u3068\u306e\u9593\u306e\u30ae\u30e3\u30c3\u30d7\u3092\u57cb\u3081\u308b\u3053\u3068\u3067\u3059\u3002\u3053\u308c\u306f\u30c8\u30e9\u30f3\u30b9\u30ec\u30fc\u30b7\u30e7\u30ca\u30eb\u30fb\u30e1\u30c7\u30a3\u30b7\u30f3\uff08\u7ffb\u8a33\u533b\u7642\uff09\u3068\u547c\u3070\u308c\u307e\u3059\u3002\u3053\u308c\u306f\u3001\u3053\u308c\u3089\u306e\u75be\u60a3\u306b\u95a2\u3059\u308b\u73fe\u5728\u306e\u57fa\u790e\u79d1\u5b66\u306e\u7406\u89e3\u3092\u6d3b\u7528\u3057\u3001\u751f\u304d\u3066\u3044\u308b\u52d5\u7269\u30e2\u30c7\u30eb\u3067\u6cbb\u7642\u4eee\u8aac\u3092\u691c\u8a3c\u3059\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u307e\u3059\u3002\u7e70\u308a\u8fd4\u3057\u53ef\u80fd\u306a\u52d5\u7269\u30e2\u30c7\u30eb\u304c\u3042\u308c\u3070\u3001\u30d0\u30a4\u30aa\u30d5\u30a1\u30fc\u30de\u4f01\u696d\u3084\u7814\u7a76\u6a5f\u95a2\u304c\u6b63\u5f0f\u306a\u6cbb\u7642\u958b\u767a\u3084\u81e8\u5e8a\u8a66\u9a13\u3092\u5b9f\u65bd\u3067\u304d\u307e\u3059\u3002<\/p>\n 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noopener\"><strong>\u30af\u30ec\u30a4\u30b0\u30fb\u30d6\u30e9\u30c3\u30af\u30b9\u30c8\u30fc\u30f3\u535a\u58eb<\/strong><\/a>\u306f\u3001\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u7dcf\u5408\u75c5\u9662\uff08MGH\uff09\u306e\u904b\u52d5\u969c\u5bb3\u90e8\u9580\u306e\u4e3b\u4efb\u3067\u3042\u308a\u3001\u30cf\u30fc\u30d0\u30fc\u30c9\u5927\u5b66\u533b\u5b66\u90e8\u306e\u795e\u7d4c\u5b66\u6559\u6388\u3067\u3059\u30022020\u5e74\u306bMGH\u306b\u6765\u308b\u524d\u3001\u30d6\u30e9\u30c3\u30af\u30b9\u30c8\u30fc\u30f3\u535a\u58eb\u306f\u56fd\u7acb\u885b\u751f\u7814\u7a76\u6240\uff08NIH\uff09\u306720\u5e74\u9593\u904e\u3054\u3057\u3001\u6700\u7d42\u7684\u306b\u306f\u795e\u7d4c\u907a\u4f1d\u5b66\u90e8\u9580\u306e\u7d30\u80de\u751f\u7269\u5b66\u30bb\u30af\u30b7\u30e7\u30f3\u306e\u4e3b\u4efb\u304a\u3088\u3073\u4e0a\u7d1a\u7814\u7a76\u8005\u3068\u3057\u3066\u6d3b\u8e8d\u3057\u307e\u3057\u305f\u3002\u5f7c\u306e\u6307\u5c0e\u306e\u4e0b\u3001\u30b0\u30eb\u30fc\u30d7\u306f\u907a\u4f1d\u6027\u904b\u52d5\u969c\u5bb3\u306e\u7d30\u80de\u304a\u3088\u3073\u5206\u5b50\u30e1\u30ab\u30cb\u30ba\u30e0\u3092\u7814\u7a76\u3057\u307e\u3057\u305f\u3002\u5f7c\u306f\u3053\u306e\u5206\u91ce\u3067\u4e16\u754c\u3092\u30ea\u30fc\u30c9\u3059\u308b\u7814\u7a76\u8005\u306e\u4e00\u4eba\u3067\u3059\u3002<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Joseph_Avellone)\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\u30b8\u30e7\u30bb\u30d5\u30fb\u30a2\u30d9\u30ed\u30fc\u30f3\u535a\u58eb<\/strong><\/a>\u306f\u3001\u9000\u8077\u3057\u305f\u5916\u79d1\u533b\u304a\u3088\u3073\u30d8\u30eb\u30b9\u30b1\u30a2\u7ba1\u7406\u8005\u3067\u3001de novo\u306e\u8907\u96d1\u306aSPG3A\u3092\u6301\u3064\u5b6b\u306e\u30ab\u30fc\u30bf\u30fc\u304c\u3044\u307e\u3059\u3002\u5f7c\u306f\u4ed6\u306e\u5bb6\u65cf\u3068\u3068\u3082\u306b<strong>\u30ab\u30fc\u30bf\u30fc\u795e\u7d4c\u7814\u7a76\u8ca1\u56e3<\/strong>\u3092\u8a2d\u7acb\u3057\u307e\u3057\u305f\u3002<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-early-onset-hsp-natural-history-study\"} -->\n    <div class=\"ghostkit-accordion-item\" 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href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>\u5c0f\u5150\u671f\u767a\u75c7\u306e\u3059\u3079\u3066\u306e\u907a\u4f1d\u6027\u75d9\u6027\u5bfe\u9ebb\u75fa\u306e\u30ec\u30b8\u30b9\u30c8\u30ea<\/strong><\/a>\u3092\u69cb\u7bc9\u3057\u3066\u3044\u307e\u3059\uff08<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04712812?cond=NCT04712812&#038;draw=2&#038;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\">\u65e9\u671f\u767a\u75c7\u907a\u4f1d\u6027\u75d9\u6027\u5bfe\u9ebb\u75fa\u306e\u305f\u3081\u306e\u30ec\u30b8\u30b9\u30c8\u30ea\u304a\u3088\u3073\u81ea\u7136\u53f2\u7814\u7a76<\/a>\uff09\u3002<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u81ea\u7136\u53f2\u7814\u7a76\u306f\u3001\u5e0c\u5c11\u75be\u60a3\u306b\u3068\u3063\u3066\u6975\u3081\u3066\u91cd\u8981\u3067\u3059\u3002\u305d\u308c\u304c\u306a\u3051\u308c\u3070\u3001\u6cbb\u7642\u306e\u9078\u629e\u80a2\u306f\u5229\u7528\u3067\u304d\u307e\u305b\u3093\u3002\u30ab\u30fc\u30bf\u30fc\u795e\u7d4c\u7814\u7a76\u8ca1\u56e3\u306e\u7814\u7a76\u30d7\u30ed\u30b0\u30e9\u30e0\u304b\u3089\u751f\u3058\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u3082\u306e\u3092\u542b\u3081\u3001\u5c0f\u5150HSP\u306e\u6cbb\u7642\u306b\u95a2\u3059\u308b\u5c06\u6765\u306e\u81e8\u5e8a\u8a66\u9a13\u306f\u3001\u3053\u306e\u30ec\u30b8\u30b9\u30c8\u30ea\u306b\u4f9d\u5b58\u3059\u308b\u53ef\u80fd\u6027\u304c\u9ad8\u3044\u3067\u3059\u3002<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><strong>\u3053\u306e\u7814\u7a76\u306f\u73fe\u5728\u3082\u4e16\u754c\u4e2d\u3067\u53c2\u52a0\u8005\u3092\u52df\u96c6\u3057\u3066\u3044\u307e\u3059\u3002<\/strong>2022\u5e748\u6708\u6642\u70b9\u3067\u3001<a href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>\u30ec\u30b8\u30b9\u30c8\u30ea\u306b\u306fSPG3A\u306e\u75c7\u4f8b\u304c\u308f\u305a\u304b11\u4ef6\u3057\u304b<\/strong>\u3042\u308a\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u3082\u3057\u3042\u306a\u305f\u304cSPG3A\u3092\u6301\u3063\u3066\u3044\u3066\u3001\u307e\u3060\u767b\u9332\u3057\u3066\u3044\u306a\u3044\u5834\u5408\u3001\u7814\u7a76\u30b3\u30fc\u30c7\u30a3\u30cd\u30fc\u30bf\u30fc\u306e<br><a href=\"http:\/\/sahin-lab.org\/people\/catherine-jordan-ms\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\u30a8\u30a4\u30df\u30fc\u30fb\u30bf\u30e0<\/strong><\/a>\u306b\u30e1\u30fc\u30eb\u3067\u9023\u7d61\u3059\u308b\u3053\u3068\u3092\u5f37\u304f\u304a\u52e7\u3081\u3057\u307e\u3059\uff1a<br><a href=\"http:\/\/Catherine.Jordan@childrens.harvard.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>amy.tam@childrens.harvard.edu<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u53c2\u52a0\u306f\u7121\u6599\u3067\u3001\u30c0\u30ea\u30a6\u30b9\u535a\u58eb\u3068\u306e1\u6642\u9593\u306eZoom\u76f8\u8ac7\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u53c2\u52a0\u57fa\u6e96\uff1a<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:list -->\n        <ul class=\"wp-block-list\">\n          <!-- wp:list-item -->\n          <li>\u907a\u4f1d\u6027\u75d9\u6027\u5bfe\u9ebb\u75fa\u306e\u75c7\u72b6\u304c18\u6b73\u4ee5\u524d\u306b\u767a\u75c7<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>\u73fe\u5728\u306e\u5e74\u9f62\u304c30\u6b73\u672a\u6e80<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>HSP\u95a2\u9023\u907a\u4f1d\u5b50\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3064\u3001\u307e\u305f\u306f\u305d\u306e\u3088\u3046\u306a\u8a3a\u65ad\u3092\u6301\u3064\u89aa\u65cf\u304c\u3044\u308b<\/li>\n          <!-- \/wp:list-item -->\n        <\/ul>\n        <!-- \/wp:list -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\" aria-expanded=\"false\" aria-controls=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\">\n          <span class=\"ghostkit-accordion-item-label\">NIH\u4e3b\u50ac\u306eDe Novo SPG4\u30b7\u30f3\u30dd\u30b8\u30a6\u30e0\u304b\u3089\u306eSPG3A\u306b\u95a2\u3059\u308b\u7d50\u8ad6<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\">\n        <!-- wp:paragraph -->\n        <p>\u30dc\u30b9\u30c8\u30f3\u306e\u30de\u30b5\u30c1\u30e5\u30fc\u30bb\u30c3\u30c4\u7dcf\u5408\u75c5\u9662\u306e\u30af\u30ec\u30a4\u30b0\u30fb\u30d6\u30e9\u30c3\u30af\u30b9\u30c8\u30fc\u30f3\u535a\u58eb\u306f\u3001HSP\u3001\u7279\u306bSPG3A\u306e\u5206\u91ce\u3067\u30c8\u30c3\u30d7\u306e\u7814\u7a76\u8005\u306e\u4e00\u4eba\u3067\u3059\u3002<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u30ab\u30fc\u30bf\u30fc\u795e\u7d4c\u75be\u60a3\u7814\u7a76\u8ca1\u56e3\u3068\u5354\u529b\u3057\u3066\u3001in vitro\u304a\u3088\u3073in vivo\u30e2\u30c7\u30eb\u3067\u3055\u307e\u3056\u307e\u306a\u85ac\u7269\u5316\u5408\u7269\u3084\u907a\u4f1d\u5b50\u6cbb\u7642\u6cd5\u3092\u30c6\u30b9\u30c8\u3057\u3001\u8fd1\u672a\u6765\u306bde novo SPG3A\u306e\u5b50\u3069\u3082\u305f\u3061\u3092\u5bfe\u8c61\u3068\u3057\u305f\u81e8\u5e8a\u8a66\u9a13\u3092\u8a2d\u8a08\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u30d6\u30e9\u30c3\u30af\u30b9\u30c8\u30fc\u30f3\u535a\u58eb\u306e\u7814\u7a76\u306e\u30d7\u30ec\u30bc\u30f3\u30c6\u30fc\u30b7\u30e7\u30f3\u306f\u300124\u520632\u79d2\u304b\u3089\u3053\u3061\u3089\u3067\u3054\u89a7\u3044\u305f\u3060\u3051\u307e\u3059\uff1a<a href=\"https:\/\/videocast.nih.gov\/watch=44694\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/videocast.nih.gov\/watch=44694<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u5f7c\u306e\u30d7\u30ec\u30bc\u30f3\u30c6\u30fc\u30b7\u30e7\u30f3\u304b\u3089\u306e\u30b9\u30ca\u30c3\u30d7\u30b7\u30e7\u30c3\u30c8\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\uff1a<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u30d6\u30e9\u30c3\u30af\u30b9\u30c8\u30fc\u30f3\u535a\u58eb\u3068\u30ab\u30fc\u30bf\u30fc\u8ca1\u56e3\u306f\u3001\u5c06\u6765\u306e\u81e8\u5e8a\u8a66\u9a13\u306e\u8a2d\u8a08\u306b\u304a\u3044\u3066\u3001\u4e0a\u8ff0\u306e\u30dc\u30b9\u30c8\u30f3\u5c0f\u5150\u75c5\u9662\u306eHSP\u81ea\u7136\u53f2\u7814\u7a76\u306b\u4f9d\u5b58\u3057\u307e\u3059\u3002<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-mutational-cluster-causing-more-severe-spg3a\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-mutational-cluster-causing-more-severe-spg3a\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\" aria-expanded=\"false\" aria-controls=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\">\n          <span class=\"ghostkit-accordion-item-label\">\u3088\u308a\u91cd\u7be4\u306aSPG3A\u3092\u5f15\u304d\u8d77\u3053\u3059\u5909\u7570\u30af\u30e9\u30b9\u30bf<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\">\n        <!-- wp:paragraph -->\n        <p>\u7814\u7a76\u8005\u306e\u30b8\u30e5\u30ea\u30a2\u30f3\u30fbE\u30fb\u30a2\u30ec\u30af\u3001\u30a2\u30d5\u30b7\u30f3\u30fb\u30b5\u30d5\u30a1\u30ea\u3001\u30ad\u30e3\u30b5\u30ea\u30f3\u30fb\u30b8\u30e7\u30fc\u30c0\u30f3\u3001\u30b7\u30c3\u30c0\u30fc\u30eb\u30c8\u30fb\u30b9\u30ea\u30d0\u30b9\u30bf\u30d0\u3001\u30af\u30ec\u30a4\u30b0\u30fb\u30d6\u30e9\u30c3\u30af\u30b9\u30c8\u30fc\u30f3\u3001\u30c0\u30ea\u30a6\u30b9\u30fb\u30a8\u30d6\u30e9\u30d2\u30df-\u30d5\u30a1\u30cf\u30ea\u306f\u3001537\u4eba\u306eSPG3A\u60a3\u8005\u306e\u6a2a\u65ad\u7684\u5206\u6790\u3092\u884c\u3044\u3001\u305d\u306e\u3046\u306131\u4eba\u304cde novo ATL1\u30d0\u30ea\u30a2\u30f3\u30c8\u3092\u6301\u3063\u3066\u3044\u307e\u3057\u305f\u3002<br><br>\u5f7c\u3089\u306f\u30013\u6b21\u5143\u306e\u5909\u7570\u30af\u30e9\u30b9\u30bf\u5185\u306b\u4f4d\u7f6e\u3059\u308b\u7279\u5b9a\u306e\u30d0\u30ea\u30a2\u30f3\u30c8\u304c\u3001\u4e0b\u80a2\u306e\u307f\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u5358\u7d14\u306aHSP\u3092\u8d85\u3048\u308b\u3088\u308a\u91cd\u7be4\u306a\u75c7\u72b6\u3092\u5f15\u304d\u8d77\u3053\u3059\u3053\u3068\u3092\u767a\u898b\u3057\u307e\u3057\u305f\u3002\u3088\u308a\u8907\u96d1\u306a\u75c7\u72b6\u306b\u306f\u3001\u767a\u9054\u795e\u7d4c\u7570\u5e38\u3001\u4e0a\u80a2\u306e\u75d9\u6027\u3001\u7403\u90e8\u75c7\u72b6\uff08\u69cb\u97f3\u969c\u5bb3\u3001\u56a5\u4e0b\u969c\u5bb3\u306a\u3069\uff09\u3001\u672b\u68a2\u795e\u7d4c\u969c\u5bb3\u3001\u8133\u753b\u50cf\u7570\u5e38\u304c\u542b\u307e\u308c\u307e\u3059\u3002<br><br>\u3053\u306e\u30af\u30e9\u30b9\u30bf\u3067\u7279\u5b9a\u3055\u308c\u305f\u30d0\u30ea\u30a2\u30f3\u30c8\u306f\u4ee5\u4e0b\u306e\u901a\u308a\u3067\u3059\uff1a<strong>Ala350, Arg403, Arg415, Arg416, Asn355, Gly409, Gly410, Leu401, Lys407, Met347, Met408, Phe413, Pro344, Ser346, Ser398, Ser414, Tyr417, Val405<\/strong>\u3002<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u5f7c\u3089\u306e\u767a\u898b\u306f\u3001ATL1\u5909\u7570\u306e\u30b8\u30a7\u30ce\u30bf\u30a4\u30d7-\u30d5\u30a7\u30ce\u30bf\u30a4\u30d7\u95a2\u4fc2\u3092\u78ba\u7acb\u3057\u307e\u3059\u3002\u3053\u306e\u5909\u7570\u30af\u30e9\u30b9\u30bf\u306f\u3001\u5c06\u6765\u306e\u6cbb\u7642\u30aa\u30d7\u30b7\u30e7\u30f3\u306b\u60c5\u5831\u3092\u63d0\u4f9b\u3057\u307e\u3059\u3002<br><strong>\u200d<\/strong><br>\u6284\u9332\u306f<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35925862\/\" target=\"_blank\" rel=\"noreferrer noopener\">\u3053\u3061\u3089<\/a>\u3067\u8aad\u3081\u307e\u3059\u3002<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:image {\"id\":151,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n        <figure class=\"wp-block-image 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