{"id":150,"date":"2025-04-28T17:51:29","date_gmt":"2025-04-28T17:51:29","guid":{"rendered":"https:\/\/honeydew-hyena-350809.hostingersite.com\/?page_id=150"},"modified":"2025-05-08T12:59:25","modified_gmt":"2025-05-08T12:59:25","slug":"research","status":"publish","type":"page","link":"https:\/\/kidswithspg3a.com\/ko\/research\/","title":{"rendered":"\uc5f0\uad6c"},"content":{"rendered":"<!-- wp:spacer -->\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:group {\"style\":{\"color\":{\"background\":\"#ffffff91\"}},\"layout\":{\"type\":\"constrained\"}} -->\n<div class=\"wp-block-group has-background\" style=\"background-color:#ffffff91\">\n  <!-- wp:heading {\"level\":1} -->\n  <h1 class=\"wp-block-heading\" id=\"research\">\uc5f0\uad6c<\/h1>\n  <!-- \/wp:heading -->\n\n  <!-- wp:ghostkit\/accordion {\"itemsCount\":4,\"collapseOne\":true,\"collapseTitleTag\":\"h2\"} -->\n  <div class=\"ghostkit-accordion ghostkit-accordion-4 ghostkit-accordion-collapse-one\">\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-the-carter-foundation-research-program\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-the-carter-foundation-research-program\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-the-carter-foundation-research-program-button\" aria-expanded=\"false\" aria-controls=\"accordion-the-carter-foundation-research-program-content\">\n          <span class=\"ghostkit-accordion-item-label\">\uce74\ud130 \uc7ac\ub2e8 \uc5f0\uad6c \ud504\ub85c\uadf8\ub7a8<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-the-carter-foundation-research-program-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-the-carter-foundation-research-program-button\">\n        <!-- wp:embed {\"url\":\"https:\/\/www.youtube.com\/watch?v=LNd_Oog5fiU\",\"type\":\"video\",\"providerNameSlug\":\"youtube\",\"responsive\":true,\"className\":\"wp-embed-aspect-16-9 wp-has-aspect-ratio\"} -->\n        <figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\">\n          <div class=\"wp-block-embed__wrapper\">\n            <iframe loading=\"lazy\" title=\"Carter Foundation SPG3A Research Program Update - February 2025\" width=\"1290\" height=\"726\" src=\"https:\/\/www.youtube.com\/embed\/LNd_Oog5fiU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n          <\/div>\n        <\/figure>\n        <!-- \/wp:embed -->\n\n        <!-- wp:paragraph -->\n        <p><strong>\uce74\ud130 \uc7ac\ub2e8<\/strong>\uc758 \uc0ac\uba85\uc740 \uc720\uc804\uc131 \uacbd\uc9c1\uc131 \ud558\ubc18\uc2e0 \ub9c8\ube44(HSP) \uc544\ub3d9\uc744 \uc704\ud55c \uce58\ub8cc\ubc95\uacfc \uc694\ubc95\uc758 \uac1c\ubc1c\uc744 \uac00\ub2a5\ud558\uac8c \ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \ud604\uc7ac HSP\uc758 \uac00\uc7a5 \ud754\ud55c \ub450 \uac00\uc9c0 \ud615\ud0dc\uc778 SPG3A\uc640 SPG4\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd94\uace0 \uc788\uc73c\uba70, \ud2b9\ud788 \uc870\uae30 \ubc1c\ubcd1 \ub3cc\uc5f0\ubcc0\uc774\uc640 \uc885\uc885 \ub4dc \ub178\ubcf4(de novo) \uc0c1\ud0dc\uc5d0 \uc911\uc810\uc744 \ub450\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\uc7ac\ub2e8\uc758 \ub178\ub825\uc740 \uc774\ub7ec\ud55c \uc0c1\ud0dc\uc5d0 \ub300\ud55c \uae30\ubcf8 \uc138\ud3ec \ubc0f \uc720\uc804\uc801 \uc774\ud574\uc640 \uce58\ub8cc\ubc95 \uac1c\ubc1c \uc0ac\uc774\uc758 \uac04\uadf9\uc744 \uba54\uc6b0\ub294 \uac83\uc785\ub2c8\ub2e4. \uc774\ub97c \uc911\uac1c \uc758\ud559(Translational Medicine)\uc774\ub77c\uace0 \ud569\ub2c8\ub2e4. \uc774\ub294 \uc774\ub7ec\ud55c \uc0c1\ud0dc\uc5d0 \ub300\ud55c \ud604\uc7ac\uc758 \uae30\ucd08 \uacfc\ud559\uc801 \uc774\ud574\ub97c \ubc14\ud0d5\uc73c\ub85c \uc0b4\uc544\uc788\ub294 \ub3d9\ubb3c \ubaa8\ub378\uc5d0\uc11c \uce58\ub8cc \uac00\uc124\uc744 \uac80\uc99d\ud558\ub294 \uac83\uc744 \uc758\ubbf8\ud569\ub2c8\ub2e4. \uc7ac\ud604 \uac00\ub2a5\ud55c \ub3d9\ubb3c \ubaa8\ub378\uc774 \uc788\uc73c\uba74 \ubc14\uc774\uc624\uc81c\uc57d \ud68c\uc0ac\uc640 \uc5f0\uad6c\uc18c\uc5d0\uc11c \uacf5\uc2dd\uc801\uc778 \uce58\ub8cc \uac1c\ubc1c\uacfc \uc784\uc0c1 \uc2dc\ud5d8\uc744 \uc9c4\ud589\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\uc774 \ube44\ub514\uc624\uc5d0\uc11c \ube14\ub799\uc2a4\ud1a4 \ubc15\uc0ac\uc640 \uc544\ubca8\ub860 \ubc15\uc0ac\ub294 \uc7ad\uc2a8 \uc5f0\uad6c\uc18c\uc5d0\uc11c \uac1c\ubc1c\ub41c SPG3A \ub9c8\uc6b0\uc2a4 \ubaa8\ub378\uc5d0\uc11c \ub2e4\uc74c \ub124 \uac00\uc9c0 \uce58\ub8cc \uac00\uc124\uc744 \uc5f0\uad6c\ud558\ub294 <strong>\uce74\ud130 \uc7ac\ub2e8 \uc5f0\uad6c \ud504\ub85c\uadf8\ub7a8\uc758 \ucd5c\uc2e0 \ubc1c\uc804<\/strong>\uc5d0 \ub300\ud574 \ub17c\uc758\ud569\ub2c8\ub2e4:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>&#8211; \uc9c0\uc9c8 \uc870\uc808\uc81c<br>&#8211; \ubf08 \ud615\uc131 \ub2e8\ubc31\uc9c8(BMP) \uc2e0\ud638 \uacbd\ub85c \uc5b5\uc81c<br>&#8211; \uc548\ud2f0\uc13c\uc2a4 \uc62c\ub9ac\uace0\ub274\ud074\ub808\uc624\ud0c0\uc774\ub4dc(ASO) \uc694\ubc95<br>&#8211; \uace0\uae09 \uc720\uc804\uc790 \ud3b8\uc9d1(\ubca0\uc774\uc2a4 \ud3b8\uc9d1)<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\uc608\uc0c1 \uae30\uac04: 1~2\ub144. \uadf8\ub7ec\ub098 \uc720\ub9dd\ud55c \ucd08\uae30 \uacb0\uacfc\uac00 \ud655\uc778\ub418\ub294 \uc989\uc2dc \uad00\ub828 \ubc14\uc774\uc624\uc81c\uc57d \ud68c\uc0ac \ubc0f \uae30\uad00\ub4e4\uacfc \ubcd1\ud589\ud558\uc5ec \ub17c\uc758\ub97c \uc2dc\uc791\ud560 \uacc4\ud68d\uc785\ub2c8\ub2e4.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/www.massgeneral.org\/doctors\/21073\/craig-blackstone\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\ud06c\ub808\uc774\uadf8 \ube14\ub799\uc2a4\ud1a4 \ubc15\uc0ac<\/strong><\/a>\ub294 \ub9e4\uc0ac\ucd94\uc138\uce20 \uc885\ud569\ubcd1\uc6d0(MGH)\uc758 \uc6b4\ub3d9 \uc7a5\uc560 \ubd80\uc11c \ucc45\uc784\uc790\uc774\uba70 \ud558\ubc84\ub4dc \uc758\uacfc\ub300\ud559\uc758 \uc2e0\uacbd\uacfc \uad50\uc218\uc785\ub2c8\ub2e4. 2020\ub144\uc5d0 MGH\uc5d0 \ud569\ub958\ud558\uae30 \uc804, \ube14\ub799\uc2a4\ud1a4 \ubc15\uc0ac\ub294 \uad6d\ub9bd\ubcf4\uac74\uc6d0(NIH)\uc5d0\uc11c 20\ub144\uc744 \ubcf4\ub0c8\uc73c\uba70, \ub9c8\uc9c0\ub9c9\uc73c\ub85c \uc2e0\uacbd\uc720\uc804\ud559 \ubd84\uacfc\uc758 \uc138\ud3ec \uc0dd\ubb3c\ud559 \uc139\uc158 \ucc45\uc784\uc790\uc774\uc790 \uc120\uc784 \uc5f0\uad6c\uc790\ub85c \ud65c\ub3d9\ud588\uc2b5\ub2c8\ub2e4. \uadf8\uc758 \uc9c0\ub3c4 \uc544\ub798 \uadf8\uc758 \uadf8\ub8f9\uc740 \uc720\uc804\uc131 \uc6b4\ub3d9 \uc7a5\uc560\uc758 \uc138\ud3ec \ubc0f \ubd84\uc790 \uba54\ucee4\ub2c8\uc998\uc744 \uc870\uc0ac\ud588\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \uc774 \ubd84\uc57c\uc5d0\uc11c \uc138\uacc4\uc801\uc778 \uc120\ub3c4 \uc5f0\uad6c\uc790 \uc911 \ud55c \uba85\uc785\ub2c8\ub2e4.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Joseph_Avellone)\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\uc870\uc149 \uc544\ubca8\ub860 \ubc15\uc0ac<\/strong><\/a>\ub294 \uc740\ud1f4\ud55c \uc678\uacfc \uc758\uc0ac\uc774\uc790 \ud5ec\uc2a4\ucf00\uc5b4 \uc784\uc6d0\uc73c\ub85c, \ub4dc \ub178\ubcf4 \ubcf5\ud569 SPG3A\ub97c \uc553\uace0 \uc788\ub294 \uc190\uc790 \uce74\ud130\ub97c \ub450\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uadf8\ub294 \ub2e4\ub978 \uac00\uc871\ub4e4\uacfc \ud568\uaed8 <strong>\uce74\ud130 \uc2e0\uacbd \uc5f0\uad6c \uc7ac\ub2e8<\/strong>\uc744 \uc124\ub9bd\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-early-onset-hsp-natural-history-study\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-early-onset-hsp-natural-history-study\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-early-onset-hsp-natural-history-study-button\" aria-expanded=\"false\" aria-controls=\"accordion-early-onset-hsp-natural-history-study-content\">\n          <span class=\"ghostkit-accordion-item-label\">\uc870\uae30 \ubc1c\ubcd1 HSP \uc790\uc5f0\uc0ac \uc5f0\uad6c<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-early-onset-hsp-natural-history-study-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-early-onset-hsp-natural-history-study-button\">\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/connects.catalyst.harvard.edu\/Profiles\/display\/Person\/125033\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\ub2e4\ub9ac\uc6b0\uc2a4 \uc5d0\ube0c\ub77c\ud788\ubbf8-\ud30c\uce74\ub9ac \ubc15\uc0ac<\/strong><\/a>\ub294 <a href=\"https:\/\/www.childrenshospital.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\ubcf4\uc2a4\ud134 \uc544\ub3d9\ubcd1\uc6d0<\/strong><\/a>\uc5d0\uc11c <a href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>\uc18c\uc544\uae30 \ubc1c\ubcd1 \uc720\uc804\uc131 \uacbd\uc9c1\uc131 \ud558\ubc18\uc2e0 \ub9c8\ube44\uc758 \ubaa8\ub4e0 \uc0ac\ub840\ub97c \ub4f1\ub85d\ud558\ub294 \ub808\uc9c0\uc2a4\ud2b8\ub9ac<\/strong><\/a>\ub97c \uad6c\ucd95\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4 (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT47_12812?cond=NCT47_12812&#038;draw=2&#038;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\">\uc870\uae30 \ubc1c\ubcd1 \uc720\uc804\uc131 \uacbd\uc9c1\uc131 \ud558\ubc18\uc2e0 \ub9c8\ube44\ub97c \uc704\ud55c \ub808\uc9c0\uc2a4\ud2b8\ub9ac \ubc0f \uc790\uc5f0\uc0ac \uc5f0\uad6c<\/a>).<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\uc790\uc5f0\uc0ac \uc5f0\uad6c\ub294 \ud76c\uadc0 \uc9c8\ud658\uc5d0 \ub9e4\uc6b0 \uc911\uc694\ud569\ub2c8\ub2e4. \uc774\uac83\uc774 \uc5c6\uc73c\uba74 \uce58\ub8cc \uc635\uc158\uc774 \uc81c\uacf5\ub418\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uce74\ud130 \uc2e0\uacbd \uc5f0\uad6c \uc7ac\ub2e8\uc758 \uc5f0\uad6c \ud504\ub85c\uadf8\ub7a8\uc5d0\uc11c \ube44\ub86f\ub420 \uc218 \uc788\ub294 \uac83\uc744 \ud3ec\ud568\ud558\uc5ec \uc18c\uc544 HSP \uce58\ub8cc\uc640 \uad00\ub828\ub41c \ubbf8\ub798\uc758 \uc784\uc0c1 \uc2dc\ud5d8\uc740 \uc774 \ub808\uc9c0\uc2a4\ud2b8\ub9ac\uc5d0 \uc758\uc874\ud560 \uac00\ub2a5\uc131\uc774 \ub192\uc2b5\ub2c8\ub2e4.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><strong>\uc774 \uc5f0\uad6c\ub294 \uc804 \uc138\uacc4\uc801\uc73c\ub85c \ucc38\uac00\uc790\ub97c \ubaa8\uc9d1\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/strong> 2022\ub144 8\uc6d4 \uae30\uc900\uc73c\ub85c <a href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>\ub808\uc9c0\uc2a4\ud2b8\ub9ac\uc5d0\ub294 SPG3A \uc0ac\ub840\uac00 \ub2e8 11\uac74<\/strong>\ub9cc \uc788\uc5c8\uc2b5\ub2c8\ub2e4.<\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\ub9cc\uc57d \ub2f9\uc2e0\uc774 SPG3A\ub97c \uac00\uc9c0\uace0 \uc788\uace0 \uc544\uc9c1 \ub4f1\ub85d\ud558\uc9c0 \uc54a\uc558\ub2e4\uba74, \uc5f0\uad6c \ucf54\ub514\ub124\uc774\ud130 <br><a href=\"http:\/\/sahin-lab.org\/people\/catherine-jordan-ms\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>\uc5d0\uc774\ubbf8 \ud0ec<\/strong><\/a>\uc5d0\uac8c \uc774\uba54\uc77c\ub85c \uc5f0\ub77d\ud558\ub294 \uac83\uc744 \uac15\ub825\ud788 \uad8c\uc7a5\ud569\ub2c8\ub2e4: <br><a href=\"http:\/\/Catherine.Jordan@childrens.harvard.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>amy.tam@childrens.harvard.edu<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\ucc38\uac00\ub294 \ubb34\ub8cc\uc774\uba70 \ub2e4\ub9ac\uc6b0\uc2a4 \ubc15\uc0ac\uc640 1\uc2dc\uac04 \ub3d9\uc548 Zoom \uc0c1\ub2f4\uc744 \ud3ec\ud568\ud569\ub2c8\ub2e4.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\ud3ec\ud568 \uae30\uc900:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:list -->\n        <ul class=\"wp-block-list\">\n          <!-- wp:list-item -->\n          <li>\uc720\uc804\uc131 \uacbd\uc9c1\uc131 \ud558\ubc18\uc2e0 \ub9c8\ube44 \uc99d\uc0c1\uc774 18\uc138 \uc774\uc804\uc5d0 \ubc1c\ubcd1<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>\ud604\uc7ac \ub098\uc774 30\uc138 \ubbf8\ub9cc<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>HSP \uad00\ub828 \uc720\uc804\uc790 \ubcc0\uc774\ub97c \uac00\uc9c0\uac70\ub098 \uadf8\ub7ec\ud55c \uc9c4\ub2e8\uc744 \ubc1b\uc740 \uce5c\ucc99\uc774 \uc788\uc74c<\/li>\n          <!-- \/wp:list-item -->\n        <\/ul>\n        <!-- \/wp:list -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\" aria-expanded=\"false\" aria-controls=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\">\n          <span class=\"ghostkit-accordion-item-label\">NIH\uac00 \uc8fc\ucd5c\ud55c \ub4dc \ub178\ubcf4 SPG4 \uc2ec\ud3ec\uc9c0\uc5c4\uc5d0\uc11c SPG3A\uc5d0 \ub300\ud55c \uacb0\ub860<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\">\n        <!-- wp:paragraph -->\n        <p>\ubcf4\uc2a4\ud134 \ub9e4\uc0ac\ucd94\uc138\uce20 \uc885\ud569\ubcd1\uc6d0\uc758 \ud06c\ub808\uc774\uadf8 \ube14\ub799\uc2a4\ud1a4 \ubc15\uc0ac\ub294 HSP, \ud2b9\ud788 SPG3A \ubd84\uc57c\uc5d0\uc11c \uc120\ub3c4\uc801\uc778 \uc5f0\uad6c\uc790 \uc911 \ud55c \uba85\uc785\ub2c8\ub2e4.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\uce74\ud130 \uc2e0\uacbd \uc9c8\ud658 \uc5f0\uad6c \uc7ac\ub2e8\uacfc \ud611\ub825\ud558\uc5ec \uadf8\ub294 \uc778 \ube44\ud2b8\ub85c \ubc0f \uc778 \ube44\ubcf4 \ubaa8\ub378\uc5d0\uc11c \ub2e4\uc591\ud55c \uc57d\ubb3c \ud654\ud569\ubb3c\uacfc \uc720\uc804\uc790 \uce58\ub8cc \ubc29\ubc95\uc744 \ud14c\uc2a4\ud2b8\ud558\uace0 \uc788\uc73c\uba70, \uac00\uae4c\uc6b4 \ubbf8\ub798\uc5d0 \ub4dc \ub178\ubcf4 SPG3A \uc544\ub3d9\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c \uc784\uc0c1 \uc2dc\ud5d8\uc744 \uc124\uacc4\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\ube14\ub799\uc2a4\ud1a4 \ubc15\uc0ac\uc758 \uc5f0\uad6c \ubc1c\ud45c\ub294 \uc5ec\uae30\uc5d0\uc11c 24\ubd84 32\ucd08\ubd80\ud130 \ubcfc \uc218 \uc788\uc2b5\ub2c8\ub2e4: <a href=\"https:\/\/videocast.nih.gov\/watch=44694\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/videocast.nih.gov\/watch=44694<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\uadf8\uc758 \ubc1c\ud45c\uc5d0\uc11c \ubc1c\ucdcc\ud55c \uc2a4\ub0c5\uc0f7\uc740 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\ube14\ub799\uc2a4\ud1a4 \ubc15\uc0ac\uc640 \uce74\ud130 \uc7ac\ub2e8\uc740 \uc704\uc5d0 \uc124\uba85\ub41c \ubcf4\uc2a4\ud134 \uc544\ub3d9\ubcd1\uc6d0\uc758 HSP \uc790\uc5f0\uc0ac \uc5f0\uad6c\uc5d0 \uc758\uc874\ud558\uc5ec \ubbf8\ub798\uc758 \uc784\uc0c1 \uc2dc\ud5d8\uc744 \uc124\uacc4\ud560 \uac83\uc785\ub2c8\ub2e4.<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-mutational-cluster-causing-more-severe-spg3a\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-mutational-cluster-causing-more-severe-spg3a\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\" aria-expanded=\"false\" aria-controls=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\">\n          <span class=\"ghostkit-accordion-item-label\">\ub354 \uc2ec\uac01\ud55c SPG3A\ub97c \uc720\ubc1c\ud558\ub294 \ub3cc\uc5f0\ubcc0\uc774 \ud074\ub7ec\uc2a4\ud130<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\">\n        <!-- wp:paragraph -->\n        <p>\uc5f0\uad6c\uc790 \uc904\ub9ac\uc548 E. \uc54c\ub808\ucfe0, \uc544\ud504\uc2e0 \uc0ac\ud30c\ub9ac, \uce90\uc11c\ub9b0 \uc870\ub358, \uc2dc\ub2e4\ub974\uc2a4 \uc2a4\ub9ac\ubc14\uc2a4\ud0c0\ubc14, \ud06c\ub808\uc774\uadf8 \ube14\ub799\uc2a4\ud1a4, \ub2e4\ub9ac\uc6b0\uc2a4 \uc5d0\ube0c\ub77c\ud788\ubbf8-\ud30c\uce74\ub9ac\ub294 537\uba85\uc758 SPG3A \ud658\uc790\uc5d0 \ub300\ud55c \ud6a1\ub2e8\uba74 \ubd84\uc11d\uc744 \uc218\ud589\ud588\uc73c\uba70, \uc774 \uc911 31\uba85\uc774 \ub4dc \ub178\ubcf4 ATL1 \ubcc0\uc774\ub97c \uac00\uc84c\uc2b5\ub2c8\ub2e4.<br><br>\uadf8\ub4e4\uc740 3\ucc28\uc6d0 \ub3cc\uc5f0\ubcc0\uc774 \ud074\ub7ec\uc2a4\ud130 \ub0b4\uc5d0 \uc704\uce58\ud55c \ud2b9\uc815 \ubcc0\uc774\uac00 \ud558\uccb4\ub9cc \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \uc21c\uc218 HSP\ub97c \ub118\uc5b4\uc11c\ub294 \ub354 \uc2ec\uac01\ud55c \uc99d\uc0c1\uc744 \uc720\ubc1c\ud55c\ub2e4\ub294 \uac83\uc744 \ubc1c\uacac\ud588\uc2b5\ub2c8\ub2e4. \ub354 \ubcf5\uc7a1\ud55c \uc99d\uc0c1\uc5d0\ub294 \uc2e0\uacbd\ubc1c\ub2ec \uc774\uc0c1, \uc0c1\uc9c0 \uacbd\uc9c1, \uad6c\uadfc \uc99d\uc0c1(\uad6c\uc74c \uc7a5\uc560, \uc5f0\ud558 \uace4\ub780 \ub4f1), \ub9d0\ucd08 \uc2e0\uacbd\ubcd1\uc99d, \ub1cc \uc601\uc0c1 \uc774\uc0c1 \ub4f1\uc774 \ud3ec\ud568\ub429\ub2c8\ub2e4.<br><br>\uc774 \ud074\ub7ec\uc2a4\ud130\uc5d0\uc11c \ud655\uc778\ub41c \ubcc0\uc774\ub294 \ub2e4\uc74c\uacfc \uac19\uc2b5\ub2c8\ub2e4: <strong>Ala350, Arg403, Arg415, Arg416, Asn355, Gly409, Gly410, Leu401, Lys407, Met347, Met408, Phe413, Pro344, Ser346, Ser398, Ser414, Tyr417, Val405<\/strong>.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\uadf8\ub4e4\uc758 \ubc1c\uacac\uc740 ATL1 \ub3cc\uc5f0\ubcc0\uc774\uc5d0 \ub300\ud55c \uc720\uc804\uc790\ud615-\ud45c\ud604\ud615 \uad00\uacc4\ub97c \ud655\ub9bd\ud569\ub2c8\ub2e4. \uc774 \ub3cc\uc5f0\ubcc0\uc774 \ud074\ub7ec\uc2a4\ud130\ub294 \ubbf8\ub798\uc758 \uce58\ub8cc \uc635\uc158\uc5d0 \uc815\ubcf4\ub97c \uc81c\uacf5\ud560 \uac83\uc785\ub2c8\ub2e4.<br><strong>\u200d<\/strong><br>\ucd08\ub85d\uc740 <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35925862\/\" target=\"_blank\" rel=\"noreferrer noopener\">\uc5ec\uae30<\/a>\uc5d0\uc11c \uc77d\uc744 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:image {\"id\":151,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n        <figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1355\" height=\"913\" src=\"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18.png\" alt=\"\" class=\"wp-image-151\" title=\"\" srcset=\"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18.png 1355w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-300x202.png 300w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-1024x690.png 1024w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-768x517.png 768w\" sizes=\"auto, (max-width: 1355px) 100vw, 1355px\" \/><\/figure>\n        <!-- \/wp:image -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n  <\/div>\n  <!-- \/wp:ghostkit\/accordion -->\n<\/div>\n<!-- \/wp:group -->","protected":false},"excerpt":{"rendered":"<p>\uc5f0\uad6c \uce74\ud130 \uc7ac\ub2e8 \uc5f0\uad6c \ud504\ub85c\uadf8\ub7a8 \uce74\ud130 \uc7ac\ub2e8\uc758 \uc0ac\uba85\uc740 \uc720\uc804\uc131 \uacbd\uc9c1\uc131 \ud558\ubc18\uc2e0 \ub9c8\ube44(HSP) \uc544\ub3d9\uc744 \uc704\ud55c \uce58\ub8cc\ubc95\uacfc \uc694\ubc95\uc758 \uac1c\ubc1c\uc744 \uac00\ub2a5\ud558\uac8c \ud558\ub294 \uac83\uc785\ub2c8\ub2e4. \ud604\uc7ac HSP\uc758 \uac00\uc7a5 \ud754\ud55c \ub450 \uac00\uc9c0 \ud615\ud0dc\uc778 SPG3A\uc640 SPG4\uc5d0 \ucd08\uc810\uc744 \ub9de\ucd94\uace0 \uc788\uc73c\uba70, \ud2b9\ud788 \uc870\uae30 \ubc1c\ubcd1 \ub3cc\uc5f0\ubcc0\uc774\uc640 \uc885\uc885 \ub4dc \ub178\ubcf4(de novo) \uc0c1\ud0dc\uc5d0 \uc911\uc810\uc744 \ub450\uace0 \uc788\uc2b5\ub2c8\ub2e4. \uc7ac\ub2e8\uc758 \ub178\ub825\uc740 \uc774\ub7ec\ud55c \uc0c1\ud0dc\uc5d0 \ub300\ud55c \uae30\ubcf8 \uc138\ud3ec \ubc0f \uc720\uc804\uc801 \uc774\ud574\uc640 \uce58\ub8cc\ubc95 [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ghostkit_customizer_options":"","ghostkit_custom_css":"","ghostkit_custom_js_head":"","ghostkit_custom_js_foot":"","ghostkit_typography":"","footnotes":""},"class_list":["post-150","page","type-page","status-publish","hentry"],"blocksy_meta":{"background":{"background_type":"image","background_pattern":"type-1","background_image":{"attachment_id":154,"x":0,"y":0,"url":"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f4a6c6c5db63aa2f18407_Layer-0-1-613x1024.png"},"gradient":"linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 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