{"id":150,"date":"2025-04-28T17:51:29","date_gmt":"2025-04-28T17:51:29","guid":{"rendered":"https:\/\/honeydew-hyena-350809.hostingersite.com\/?page_id=150"},"modified":"2025-05-08T12:59:25","modified_gmt":"2025-05-08T12:59:25","slug":"research","status":"publish","type":"page","link":"https:\/\/kidswithspg3a.com\/pb\/research\/","title":{"rendered":"Pesquisa"},"content":{"rendered":"<!-- wp:spacer -->\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:group {\"style\":{\"color\":{\"background\":\"#ffffff91\"}},\"layout\":{\"type\":\"constrained\"}} -->\n<div class=\"wp-block-group has-background\" style=\"background-color:#ffffff91\">\n  <!-- wp:heading {\"level\":1} -->\n  <h1 class=\"wp-block-heading\" id=\"research\">Pesquisa<\/h1>\n  <!-- \/wp:heading -->\n\n  <!-- wp:ghostkit\/accordion {\"itemsCount\":4,\"collapseOne\":true,\"collapseTitleTag\":\"h2\"} -->\n  <div class=\"ghostkit-accordion ghostkit-accordion-4 ghostkit-accordion-collapse-one\">\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-the-carter-foundation-research-program\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-the-carter-foundation-research-program\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-the-carter-foundation-research-program-button\" aria-expanded=\"false\" aria-controls=\"accordion-the-carter-foundation-research-program-content\">\n          <span class=\"ghostkit-accordion-item-label\">Programa de Pesquisa da Funda\u00e7\u00e3o Carter<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-the-carter-foundation-research-program-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-the-carter-foundation-research-program-button\">\n        <!-- wp:embed {\"url\":\"https:\/\/www.youtube.com\/watch?v=LNd_Oog5fiU\",\"type\":\"video\",\"providerNameSlug\":\"youtube\",\"responsive\":true,\"className\":\"wp-embed-aspect-16-9 wp-has-aspect-ratio\"} -->\n        <figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\">\n          <div class=\"wp-block-embed__wrapper\">\n            <iframe loading=\"lazy\" title=\"Carter Foundation SPG3A Research Program Update - February 2025\" width=\"1290\" height=\"726\" src=\"https:\/\/www.youtube.com\/embed\/LNd_Oog5fiU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n          <\/div>\n        <\/figure>\n        <!-- \/wp:embed -->\n\n        <!-- wp:paragraph -->\n        <p>A miss\u00e3o da <strong>Funda\u00e7\u00e3o Carter<\/strong> \u00e9 possibilitar o desenvolvimento de terapias e tratamentos para crian\u00e7as com Paraplegia Esp\u00e1stica Heredit\u00e1ria (HSP). Atualmente, ela se concentra nas duas formas mais comuns de HSP, SPG3A e SPG4, com \u00eanfase em muta\u00e7\u00f5es de in\u00edcio precoce e, frequentemente, condi\u00e7\u00f5es de novo.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>O esfor\u00e7o da Funda\u00e7\u00e3o \u00e9 preencher a lacuna entre a compreens\u00e3o celular e gen\u00e9tica b\u00e1sica dessas condi\u00e7\u00f5es e o desenvolvimento de terapias. Isso \u00e9 chamado de Medicina Translacional. Isso significa usar o entendimento cient\u00edfico b\u00e1sico atual dessas condi\u00e7\u00f5es e testar hip\u00f3teses terap\u00eauticas em modelos animais vivos. Com um modelo animal reproduz\u00edvel, empresas biofarmac\u00eauticas e institutos podem realizar o desenvolvimento terap\u00eautico formal e ensaios cl\u00ednicos.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Neste v\u00eddeo, os doutores Blackstone e Avellone discutem <strong>os mais recentes desenvolvimentos do Programa de Pesquisa da Funda\u00e7\u00e3o Carter<\/strong>, que est\u00e1 estudando as seguintes quatro hip\u00f3teses terap\u00eauticas no modelo de camundongo SPG3A desenvolvido nos Laborat\u00f3rios Jackson:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>&#8211; Agentes de modula\u00e7\u00e3o lip\u00eddica<br>&#8211; Inibi\u00e7\u00e3o da via de sinaliza\u00e7\u00e3o de Prote\u00edna Morfog\u00eanica \u00d3ssea (BMP)<br>&#8211; Terapias com Oligonucleot\u00eddeos Antissenso (ASO)<br>&#8211; Edi\u00e7\u00e3o gen\u00e9tica avan\u00e7ada (edi\u00e7\u00e3o de bases)<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Prazo esperado: 1 a 2 anos. No entanto, assim que resultados iniciais promissores forem observados, o plano ser\u00e1 iniciar discuss\u00f5es com empresas biofarmac\u00eauticas e institutos relevantes em paralelo.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/www.massgeneral.org\/doctors\/21073\/craig-blackstone\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Dr. Craig Blackstone<\/strong><\/a> \u00e9 o chefe da Divis\u00e3o de Dist\u00farbios do Movimento no Massachusetts General Hospital (MGH) e professor de Neurologia na Harvard Medical School. Antes de ingressar no MGH em 2020, o Dr. Blackstone passou 20 anos nos National Institutes of Health, onde foi, por \u00faltimo, Investigador S\u00eanior e Chefe da Se\u00e7\u00e3o de Biologia Celular dentro do Ramo de Neurogen\u00e9tica. Sob sua lideran\u00e7a, seu grupo investigou os mecanismos celulares e moleculares dos dist\u00farbios do movimento heredit\u00e1rios. Ele \u00e9 um dos principais pesquisadores do mundo nesse campo.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Joseph_Avellone)\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Dr. Joseph Avellone<\/strong><\/a>, cirurgi\u00e3o aposentado e executivo de sa\u00fade, tem um neto, Carter, que sofre de SPG3A complexo de novo. Junto com outros membros da fam\u00edlia, ele fundou a <strong>Funda\u00e7\u00e3o Carter para Pesquisa Neurol\u00f3gica<\/strong>.<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-early-onset-hsp-natural-history-study\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-early-onset-hsp-natural-history-study\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-early-onset-hsp-natural-history-study-button\" aria-expanded=\"false\" aria-controls=\"accordion-early-onset-hsp-natural-history-study-content\">\n          <span class=\"ghostkit-accordion-item-label\">Estudo de Hist\u00f3ria Natural do HSP de In\u00edcio Precoce<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-early-onset-hsp-natural-history-study-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-early-onset-hsp-natural-history-study-button\">\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/connects.catalyst.harvard.edu\/Profiles\/display\/Person\/125033\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Dr. Darius Ebrahimi-Fakhari<\/strong><\/a> do <a href=\"https:\/\/www.childrenshospital.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Hospital Infantil de Boston<\/strong><\/a> est\u00e1 construindo <a href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>um registro de todas as Paraplegias Esp\u00e1sticas Heredit\u00e1rias de in\u00edcio pedi\u00e1trico<\/strong><\/a> (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT47_12812?cond=NCT47_12812&#038;draw=2&#038;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\">Registro e Estudo de Hist\u00f3ria Natural para Paraplegia Esp\u00e1stica Heredit\u00e1ria de In\u00edcio Precoce<\/a>).<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Estudos de hist\u00f3ria natural s\u00e3o cruciais para doen\u00e7as raras. Sem eles, op\u00e7\u00f5es de tratamento n\u00e3o estar\u00e3o dispon\u00edveis. Ensaios cl\u00ednicos futuros relacionados a curas para HSP pedi\u00e1trica, incluindo aqueles que podem surgir do programa de pesquisa da Funda\u00e7\u00e3o Carter para Pesquisa Neurol\u00f3gica, provavelmente depender\u00e3o deste registro.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><strong>O estudo ainda est\u00e1 buscando participantes globalmente.<\/strong> Em agosto de 2022, <a href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>o registro tinha apenas 11 casos de SPG3A<\/strong>.<\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Se voc\u00ea tem SPG3A e ainda n\u00e3o se registrou, recomendamos fortemente que entre em contato com <br><a href=\"http:\/\/sahin-lab.org\/people\/catherine-jordan-ms\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Amy Tam<\/strong><\/a>, a coordenadora do estudo, por e-mail: <br><a href=\"http:\/\/Catherine.Jordan@childrens.harvard.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>amy.tam@childrens.harvard.edu<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>A participa\u00e7\u00e3o \u00e9 GRATUITA e envolve uma consulta de 1 hora via Zoom com o Dr. Darius.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Crit\u00e9rios de inclus\u00e3o:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:list -->\n        <ul class=\"wp-block-list\">\n          <!-- wp:list-item -->\n          <li>In\u00edcio dos sintomas de paraplegia esp\u00e1stica heredit\u00e1ria antes dos 18 anos<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>Idade atual inferior a 30 anos<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>Ter variantes em genes relacionados ao HSP e\/ou um parente com tal diagn\u00f3stico<\/li>\n          <!-- \/wp:list-item -->\n        <\/ul>\n        <!-- \/wp:list -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\" aria-expanded=\"false\" aria-controls=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\">\n          <span class=\"ghostkit-accordion-item-label\">Conclus\u00f5es para SPG3A do Simp\u00f3sio sobre SPG4 De Novo Organizado pelo NIH<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\">\n        <!-- wp:paragraph -->\n        <p>O Dr. Craig Blackstone, do Massachusetts General Hospital em Boston, \u00e9 um dos principais pesquisadores em HSP, especificamente em SPG3A.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Em colabora\u00e7\u00e3o com a Funda\u00e7\u00e3o Carter para Pesquisa de Doen\u00e7as Neurol\u00f3gicas, ele est\u00e1 testando, tanto em modelos in vitro quanto in vivo, v\u00e1rios compostos farmacol\u00f3gicos e m\u00e9todos de terapia gen\u00e9tica com o objetivo de projetar ensaios cl\u00ednicos para crian\u00e7as com SPG3A de novo em um futuro pr\u00f3ximo.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Voc\u00ea pode assistir \u00e0 apresenta\u00e7\u00e3o da pesquisa do Dr. Blackstone aqui, a partir do minuto 24:32: <a href=\"https:\/\/videocast.nih.gov\/watch=44694\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/videocast.nih.gov\/watch=44694<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Aqui est\u00e1 um trecho de sua apresenta\u00e7\u00e3o:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>O Dr. Blackstone e a Funda\u00e7\u00e3o Carter depender\u00e3o do Estudo de Hist\u00f3ria Natural do HSP do Hospital Infantil de Boston (descrito acima) para projetar quaisquer ensaios cl\u00ednicos futuros.<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-mutational-cluster-causing-more-severe-spg3a\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-mutational-cluster-causing-more-severe-spg3a\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\" aria-expanded=\"false\" aria-controls=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\">\n          <span class=\"ghostkit-accordion-item-label\">Grupo de Muta\u00e7\u00f5es que Causa um SPG3A Mais Grave<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\">\n        <!-- wp:paragraph -->\n        <p>Os pesquisadores Julian E. Alecu, Afshin Saffari, Catherine Jordan, Siddharth Srivastava, Craig Blackstone e Darius Ebrahimi-Fakhari realizaram uma an\u00e1lise transversal de 537 pacientes com SPG3A, incluindo 31 com variantes de novo do ATL1.<br><br>Eles identificaram que certas variantes, localizadas dentro de um cluster de muta\u00e7\u00f5es tridimensional, causam sintomas mais graves que v\u00e3o al\u00e9m do HSP puro, que afeta apenas os membros inferiores. Os sintomas mais complexos incluem anormalidades do neurodesenvolvimento, espasticidade dos membros superiores, sintomas bulbares (disartria, disfagia, etc.), neuropatia perif\u00e9rica e anormalidades em imagens cerebrais.<br><br>As variantes identificadas neste cluster s\u00e3o: <strong>Ala350, Arg403, Arg415, Arg416, Asn355, Gly409, Gly410, Leu401, Lys407, Met347, Met408, Phe413, Pro344, Ser346, Ser398, Ser414, Tyr417, Val405<\/strong>.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Suas descobertas estabelecem uma rela\u00e7\u00e3o gen\u00f3tipo-fen\u00f3tipo para as muta\u00e7\u00f5es do ATL1. Este cluster de muta\u00e7\u00f5es informar\u00e1 as op\u00e7\u00f5es de tratamento futuras.<br><strong>\u200d<\/strong><br>Voc\u00ea pode ler o resumo <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35925862\/\" target=\"_blank\" rel=\"noreferrer noopener\">aqui<\/a>.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:image {\"id\":151,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n        <figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1355\" height=\"913\" src=\"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18.png\" alt=\"\" class=\"wp-image-151\" title=\"\" srcset=\"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18.png 1355w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-300x202.png 300w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-1024x690.png 1024w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-768x517.png 768w\" sizes=\"auto, (max-width: 1355px) 100vw, 1355px\" \/><\/figure>\n        <!-- \/wp:image -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n  <\/div>\n  <!-- \/wp:ghostkit\/accordion -->\n<\/div>\n<!-- \/wp:group -->","protected":false},"excerpt":{"rendered":"<p>Pesquisa Programa de Pesquisa da Funda\u00e7\u00e3o Carter A miss\u00e3o da Funda\u00e7\u00e3o Carter \u00e9 possibilitar o desenvolvimento de terapias e tratamentos para crian\u00e7as com Paraplegia Esp\u00e1stica Heredit\u00e1ria (HSP). Atualmente, ela se concentra nas duas formas mais comuns de HSP, SPG3A e SPG4, com \u00eanfase em muta\u00e7\u00f5es de in\u00edcio precoce e, frequentemente, condi\u00e7\u00f5es de novo. O esfor\u00e7o [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ghostkit_customizer_options":"","ghostkit_custom_css":"","ghostkit_custom_js_head":"","ghostkit_custom_js_foot":"","ghostkit_typography":"","footnotes":""},"class_list":["post-150","page","type-page","status-publish","hentry"],"blocksy_meta":{"background":{"background_type":"image","background_pattern":"type-1","background_image":{"attachment_id":154,"x":0,"y":0,"url":"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f4a6c6c5db63aa2f18407_Layer-0-1-613x1024.png"},"gradient":"linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%)","background_repeat":"repeat","background_size":"cover","background_attachment":"scroll","patternColor":{"default":{"color":"#e5e7ea"}},"overlayColor":{"default":{"color":"CT_CSS_SKIP_RULE"}},"backgroundColor":{"default":{"color":"#ffffff"}}},"styles_descriptor":{"styles":{"desktop":"[data-prefix=\"single_page\"] {background-position:0% 0%;background-size:cover;background-color:#ffffff;background-image:url(https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f4a6c6c5db63aa2f18407_Layer-0-1-scaled.png);}","tablet":"","mobile":""},"google_fonts":[],"version":6},"has_hero_section":"disabled"},"_links":{"self":[{"href":"https:\/\/kidswithspg3a.com\/pb\/wp-json\/wp\/v2\/pages\/150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidswithspg3a.com\/pb\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kidswithspg3a.com\/pb\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kidswithspg3a.com\/pb\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidswithspg3a.com\/pb\/wp-json\/wp\/v2\/comments?post=150"}],"version-history":[{"count":16,"href":"https:\/\/kidswithspg3a.com\/pb\/wp-json\/wp\/v2\/pages\/150\/revisions"}],"predecessor-version":[{"id":213,"href":"https:\/\/kidswithspg3a.com\/pb\/wp-json\/wp\/v2\/pages\/150\/revisions\/213"}],"wp:attachment":[{"href":"https:\/\/kidswithspg3a.com\/pb\/wp-json\/wp\/v2\/media?parent=150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}