{"id":150,"date":"2025-04-28T17:51:29","date_gmt":"2025-04-28T17:51:29","guid":{"rendered":"https:\/\/honeydew-hyena-350809.hostingersite.com\/?page_id=150"},"modified":"2025-05-08T12:59:25","modified_gmt":"2025-05-08T12:59:25","slug":"research","status":"publish","type":"page","link":"https:\/\/kidswithspg3a.com\/tr\/research\/","title":{"rendered":"Ara\u015ft\u0131rma"},"content":{"rendered":"<!-- wp:spacer -->\n<div style=\"height:100px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n<!-- \/wp:spacer -->\n\n<!-- wp:group {\"style\":{\"color\":{\"background\":\"#ffffff91\"}},\"layout\":{\"type\":\"constrained\"}} -->\n<div class=\"wp-block-group has-background\" style=\"background-color:#ffffff91\">\n  <!-- wp:heading {\"level\":1} -->\n  <h1 class=\"wp-block-heading\" id=\"research\">Ara\u015ft\u0131rma<\/h1>\n  <!-- \/wp:heading -->\n\n  <!-- wp:ghostkit\/accordion {\"itemsCount\":4,\"collapseOne\":true,\"collapseTitleTag\":\"h2\"} -->\n  <div class=\"ghostkit-accordion ghostkit-accordion-4 ghostkit-accordion-collapse-one\">\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-the-carter-foundation-research-program\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-the-carter-foundation-research-program\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-the-carter-foundation-research-program-button\" aria-expanded=\"false\" aria-controls=\"accordion-the-carter-foundation-research-program-content\">\n          <span class=\"ghostkit-accordion-item-label\">Carter Vakf\u0131 Ara\u015ft\u0131rma Program\u0131<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-the-carter-foundation-research-program-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-the-carter-foundation-research-program-button\">\n        <!-- wp:embed {\"url\":\"https:\/\/www.youtube.com\/watch?v=LNd_Oog5fiU\",\"type\":\"video\",\"providerNameSlug\":\"youtube\",\"responsive\":true,\"className\":\"wp-embed-aspect-16-9 wp-has-aspect-ratio\"} -->\n        <figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\">\n          <div class=\"wp-block-embed__wrapper\">\n            <iframe loading=\"lazy\" title=\"Carter Foundation SPG3A Research Program Update - February 2025\" width=\"1290\" height=\"726\" src=\"https:\/\/www.youtube.com\/embed\/LNd_Oog5fiU?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n          <\/div>\n        <\/figure>\n        <!-- \/wp:embed -->\n\n        <!-- wp:paragraph -->\n        <p><strong>Carter Vakf\u0131<\/strong>\u2019n\u0131n misyonu, Herediter Spastik Parapleji (HSP) hastas\u0131 \u00e7ocuklar i\u00e7in terapiler ve tedaviler geli\u015ftirmeyi m\u00fcmk\u00fcn k\u0131lmakt\u0131r. \u015eu anda HSP\u2019nin en yayg\u0131n iki formu olan SPG3A ve SPG4\u2019e odaklan\u0131yor, \u00f6zellikle erken ba\u015flang\u0131\u00e7l\u0131 mutasyonlar ve genellikle de novo durumlar \u00fczerinde duruyor.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Vakf\u0131n \u00e7abas\u0131, bu durumlar\u0131n temel h\u00fccresel ve genetik anlay\u0131\u015f\u0131yla terapi geli\u015ftirme aras\u0131ndaki bo\u015flu\u011fu kapatmakt\u0131r. Buna Translasyonel T\u0131p denir. Bu, bu durumlara dair mevcut temel bilim anlay\u0131\u015f\u0131n\u0131 almak ve canl\u0131 hayvan modellerinde tedavi hipotezlerini do\u011frulamak anlam\u0131na gelir. Tekrarlanabilir bir hayvan modeli ile biyofarma \u015firketleri ve enstit\u00fcler resmi tedavi geli\u015ftirme ve klinik denemeler yapabilir.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Bu videoda, Dr. Blackstone ve Dr. Avellone, Jackson Laboratories\u2019de geli\u015ftirilen SPG3A fare modelinde a\u015fa\u011f\u0131daki d\u00f6rt tedavi hipotezini inceleyen <strong>Carter Vakf\u0131 Ara\u015ft\u0131rma Program\u0131\u2019n\u0131n en son geli\u015fmelerini<\/strong> tart\u0131\u015f\u0131yor:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>&#8211; Lipit mod\u00fclasyon ajanlar\u0131<br>&#8211; Kemik Morfogenetik Proteini (BMP) sinyal yolu inhibisyonu<br>&#8211; Antisens Oligon\u00fckleotid (ASO) terapileri<br>&#8211; \u0130leri gen d\u00fczenleme (baz d\u00fczenleme)<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Beklenen zaman \u00e7er\u00e7evesi: 1-2 y\u0131l. Ancak, umut verici erken sonu\u00e7lar kaydedildi\u011finde, ilgili biyofarmas\u00f6tik firmalar ve enstit\u00fclerle paralel olarak g\u00f6r\u00fc\u015fmelere ba\u015flama plan\u0131 yap\u0131lacakt\u0131r.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/www.massgeneral.org\/doctors\/21073\/craig-blackstone\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Dr. Craig Blackstone<\/strong><\/a>, Massachusetts General Hospital (MGH) Hareket Bozukluklar\u0131 B\u00f6l\u00fcm\u00fc\u2019n\u00fcn ba\u015fkan\u0131 ve Harvard T\u0131p Fak\u00fcltesi\u2019nde N\u00f6roloji Profes\u00f6r\u00fc\u2019d\u00fcr. 2020\u2019de MGH\u2019ye gelmeden \u00f6nce Dr. Blackstone, Ulusal Sa\u011fl\u0131k Enstit\u00fcleri\u2019nde 20 y\u0131l ge\u00e7irdi, son olarak N\u00f6rogenetik \u015eubesi\u2019nde K\u0131demli Ara\u015ft\u0131rmac\u0131 ve H\u00fccre Biyolojisi B\u00f6l\u00fcm Ba\u015fkan\u0131 olarak g\u00f6rev yapt\u0131. Liderli\u011finde, grubu kal\u0131tsal hareket bozukluklar\u0131n\u0131n h\u00fccresel ve molek\u00fcler mekanizmalar\u0131n\u0131 ara\u015ft\u0131rd\u0131. Bu alanda d\u00fcnyan\u0131n \u00f6nde gelen ara\u015ft\u0131rmac\u0131lar\u0131ndan biridir.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/en.wikipedia.org\/wiki\/Joseph_Avellone)\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Dr. Joseph Avellone<\/strong><\/a>, emekli bir cerrah ve sa\u011fl\u0131k y\u00f6neticisi, de novo kompleks SPG3A hastas\u0131 olan torunu Carter\u2019a sahiptir. Di\u011fer aile \u00fcyeleriyle birlikte <strong>Carter N\u00f6rolojik Ara\u015ft\u0131rma Vakf\u0131<\/strong>\u2019n\u0131 kurdu.<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-early-onset-hsp-natural-history-study\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-early-onset-hsp-natural-history-study\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-early-onset-hsp-natural-history-study-button\" aria-expanded=\"false\" aria-controls=\"accordion-early-onset-hsp-natural-history-study-content\">\n          <span class=\"ghostkit-accordion-item-label\">Erken Ba\u015flang\u0131\u00e7l\u0131 HSP Do\u011fal Tarih \u00c7al\u0131\u015fmas\u0131<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-early-onset-hsp-natural-history-study-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-early-onset-hsp-natural-history-study-button\">\n        <!-- wp:paragraph -->\n        <p><a href=\"https:\/\/connects.catalyst.harvard.edu\/Profiles\/display\/Person\/125033\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Dr. Darius Ebrahimi-Fakhari<\/strong><\/a>, <a href=\"https:\/\/www.childrenshospital.org\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Boston \u00c7ocuk Hastanesi<\/strong><\/a>\u2019nden, <a href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>\u00e7ocukluk \u00e7a\u011f\u0131nda ba\u015flayan t\u00fcm Herediter Spastik Paraplejilerin bir kayd\u0131n\u0131<\/strong><\/a> olu\u015fturuyor (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04712812?cond=NCT04712812&#038;draw=2&#038;rank=1\" target=\"_blank\" rel=\"noreferrer noopener\">Erken Ba\u015flang\u0131\u00e7l\u0131 Herediter Spastik Parapleji i\u00e7in Kay\u0131t ve Do\u011fal Tarih \u00c7al\u0131\u015fmas\u0131<\/a>).<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Do\u011fal tarih \u00e7al\u0131\u015fmalar\u0131, nadir hastal\u0131klar i\u00e7in kritik \u00f6neme sahiptir. Bunlar olmadan tedavi se\u00e7enekleri mevcut olmayacakt\u0131r. \u00c7ocukluk HSP\u2019si i\u00e7in tedavilere y\u00f6nelik gelecekteki klinik denemeler, Carter N\u00f6rolojik Ara\u015ft\u0131rma Vakf\u0131\u2019n\u0131n ara\u015ft\u0131rma program\u0131ndan ortaya \u00e7\u0131kabilecek olanlar da dahil olmak \u00fczere, b\u00fcy\u00fck olas\u0131l\u0131kla bu kayda dayanacakt\u0131r.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p><strong>\u00c7al\u0131\u015fma hala d\u00fcnya genelinde kat\u0131l\u0131mc\u0131lar ar\u0131yor.<\/strong> A\u011fustos 2022 itibar\u0131yla, <a href=\"https:\/\/www.kidswithspg3a.com\/research#\"><strong>kay\u0131tta yaln\u0131zca 11 SPG3A vakas\u0131<\/strong> vard\u0131.<\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>E\u011fer SPG3A\u2019n\u0131z varsa ve hen\u00fcz kaydolmad\u0131ysan\u0131z, \u00c7al\u0131\u015fma Koordinat\u00f6r\u00fc <br><a href=\"http:\/\/sahin-lab.org\/people\/catherine-jordan-ms\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Amy Tam<\/strong><\/a> ile e-posta yoluyla ileti\u015fime ge\u00e7menizi \u015fiddetle tavsiye ederiz:<br><a href=\"http:\/\/Catherine.Jordan@childrens.harvard.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>amy.tam@childrens.harvard.edu<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Kat\u0131l\u0131m \u00dcCRETS\u0130ZD\u0130R ve Dr. Darius ile 1 saatlik bir Zoom dan\u0131\u015fmanl\u0131\u011f\u0131n\u0131 i\u00e7erir.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Kat\u0131l\u0131m kriterleri:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:list -->\n        <ul class=\"wp-block-list\">\n          <!-- wp:list-item -->\n          <li>Herediter spastik parapleji semptomlar\u0131n\u0131n 18 ya\u015f\u0131ndan \u00f6nce ba\u015flamas\u0131<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>\u015eu anki ya\u015f\u0131n 30\u2019un alt\u0131nda olmas\u0131<\/li>\n          <!-- \/wp:list-item -->\n\n          <!-- wp:list-item -->\n          <li>HSP ile ilgili genlerde varyantlara sahip olmak ve\/veya b\u00f6yle bir tan\u0131ya sahip bir akrabaya sahip olmak<\/li>\n          <!-- \/wp:list-item -->\n        <\/ul>\n        <!-- \/wp:list -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\" aria-expanded=\"false\" aria-controls=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\">\n          <span class=\"ghostkit-accordion-item-label\">NIH Taraf\u0131ndan D\u00fczenlenen De Novo SPG4 Sempozyumundan SPG3A i\u00e7in \u00c7\u0131kar\u0131mlar<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-takeaways-for-spg3a-from-de-novo-spg4-symposium-organized-by-nih-button\">\n        <!-- wp:paragraph -->\n        <p>Boston\u2019daki Massachusetts General Hospital\u2019dan Dr. Craig Blackstone, \u00f6zellikle SPG3A konusunda HSP alan\u0131nda \u00f6nde gelen ara\u015ft\u0131rmac\u0131lardan biridir.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Carter N\u00f6rolojik Hastal\u0131k Ara\u015ft\u0131rma Vakf\u0131 ile i\u015f birli\u011fi i\u00e7inde, hem in vitro hem de in vivo modellerde \u00e7e\u015fitli ila\u00e7 bile\u015fiklerini ve gen terapisi y\u00f6ntemlerini test ediyor, yak\u0131n gelecekte de novo SPG3A\u2019l\u0131 \u00e7ocuklar i\u00e7in klinik denemeler tasarlamay\u0131 ama\u00e7l\u0131yor.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Dr. Blackstone\u2019un ara\u015ft\u0131rmas\u0131n\u0131n sunumunu burada izleyebilirsiniz, 24:32\u2019nci dakikadan itibaren: <a href=\"https:\/\/videocast.nih.gov\/watch=44694\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>https:\/\/videocast.nih.gov\/watch=44694<\/strong><\/a><\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>\u0130\u015fte sunumundan bir kesit:<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Dr. Blackstone ve Carter Vakf\u0131, gelecekteki klinik denemeleri tasarlamak i\u00e7in yukar\u0131da a\u00e7\u0131klanan Boston \u00c7ocuk Hastanesi HSP Do\u011fal Tarih \u00c7al\u0131\u015fmas\u0131\u2019na dayanacakt\u0131r.<\/p>\n        <!-- \/wp:paragraph -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n\n    <!-- wp:ghostkit\/accordion-item {\"titleTag\":\"h2\",\"slug\":\"accordion-mutational-cluster-causing-more-severe-spg3a\"} -->\n    <div class=\"ghostkit-accordion-item\" data-accordion=\"accordion-mutational-cluster-causing-more-severe-spg3a\">\n      <h2 class=\"ghostkit-accordion-item-heading\">\n        <button type=\"button\" id=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\" aria-expanded=\"false\" aria-controls=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\">\n          <span class=\"ghostkit-accordion-item-label\">Daha \u015eiddetli SPG3A\u2019ya Neden Olan Mutasyon K\u00fcmesi<\/span>\n          <span class=\"ghostkit-accordion-item-collapse\">\n            <svg class=\"ghostkit-svg-icon\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n              <path d=\"M9.21967 6.2197C9.51256 5.9268 9.98744 5.9268 10.2803 6.2197L15.5303 11.4697C15.8232 11.7626 15.8232 12.2374 15.5303 12.5303L10.2803 17.7803C9.98744 18.0732 9.51256 18.0732 9.21967 17.7803C8.92678 17.4874 8.92678 17.0126 9.21967 16.7197L13.9393 12L9.21967 7.2803C8.92678 6.9874 8.92678 6.5126 9.21967 6.2197Z\" fill=\"currentColor\"><\/path>\n            <\/svg>\n          <\/span>\n        <\/button>\n      <\/h2>\n      <div id=\"accordion-mutational-cluster-causing-more-severe-spg3a-content\" class=\"ghostkit-accordion-item-content\" role=\"region\" aria-labelledby=\"accordion-mutational-cluster-causing-more-severe-spg3a-button\">\n        <!-- wp:paragraph -->\n        <p>Ara\u015ft\u0131rmac\u0131lar Julian E. Alecu, Afshin Saffari, Catherine Jordan, Siddharth Srivastava, Craig Blackstone ve Darius Ebrahimi-Fakhari, 31\u2019i de novo ATL1 varyantlar\u0131na sahip 537 SPG3A hastas\u0131 \u00fczerinde kesitsel bir analiz yapt\u0131.<br><br>\u00dc\u00e7 boyutlu bir mutasyon k\u00fcmesi i\u00e7inde yer alan baz\u0131 varyantlar\u0131n, sadece alt ekstremiteleri etkileyen saf HSP\u2019yi a\u015fan daha \u015fiddetli semptomlara neden oldu\u011funu belirlediler. Daha karma\u015f\u0131k semptomlar aras\u0131nda n\u00f6rogeli\u015fimsel anormallikler, \u00fcst ekstremite spastisitesi, bulber semptomlar (disartri, disfaji vb.), periferik n\u00f6ropati ve beyin g\u00f6r\u00fcnt\u00fcleme anormallikleri yer al\u0131r.<br><br>Bu k\u00fcmede tan\u0131mlad\u0131klar\u0131 varyantlar \u015funlard\u0131r: <strong>Ala350, Arg403, Arg415, Arg416, Asn355, Gly409, Gly410, Leu401, Lys407, Met347, Met408, Phe413, Pro344, Ser346, Ser398, Ser414, Tyr417, Val405<\/strong>.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:paragraph -->\n        <p>Bulgular\u0131, ATL1 mutasyonlar\u0131 i\u00e7in bir genotip-fenotip ili\u015fkisi kurar. Bu mutasyon k\u00fcmesi, gelecekteki tedavi se\u00e7eneklerini bilgilendirecektir.<br><strong>\u200d<\/strong><br>\u00d6zeti <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35925862\/\" target=\"_blank\" rel=\"noreferrer noopener\">burada<\/a> okuyabilirsiniz.<\/p>\n        <!-- \/wp:paragraph -->\n\n        <!-- wp:image {\"id\":151,\"sizeSlug\":\"full\",\"linkDestination\":\"none\"} -->\n        <figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"1355\" height=\"913\" src=\"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18.png\" alt=\"\" class=\"wp-image-151\" title=\"\" srcset=\"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18.png 1355w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-300x202.png 300w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-1024x690.png 1024w, https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f5d9b3010033d09384f85_Rectangle-18-768x517.png 768w\" sizes=\"auto, (max-width: 1355px) 100vw, 1355px\" \/><\/figure>\n        <!-- \/wp:image -->\n      <\/div>\n    <\/div>\n    <!-- \/wp:ghostkit\/accordion-item -->\n  <\/div>\n  <!-- \/wp:ghostkit\/accordion -->\n<\/div>\n<!-- \/wp:group --><!-- \/wp:group -->","protected":false},"excerpt":{"rendered":"<p>Ara\u015ft\u0131rma Carter Vakf\u0131 Ara\u015ft\u0131rma Program\u0131 Carter Vakf\u0131\u2019n\u0131n misyonu, Herediter Spastik Parapleji (HSP) hastas\u0131 \u00e7ocuklar i\u00e7in terapiler ve tedaviler geli\u015ftirmeyi m\u00fcmk\u00fcn k\u0131lmakt\u0131r. \u015eu anda HSP\u2019nin en yayg\u0131n iki formu olan SPG3A ve SPG4\u2019e odaklan\u0131yor, \u00f6zellikle erken ba\u015flang\u0131\u00e7l\u0131 mutasyonlar ve genellikle de novo durumlar \u00fczerinde duruyor. Vakf\u0131n \u00e7abas\u0131, bu durumlar\u0131n temel h\u00fccresel ve genetik anlay\u0131\u015f\u0131yla terapi geli\u015ftirme [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ghostkit_customizer_options":"","ghostkit_custom_css":"","ghostkit_custom_js_head":"","ghostkit_custom_js_foot":"","ghostkit_typography":"","footnotes":""},"class_list":["post-150","page","type-page","status-publish","hentry"],"blocksy_meta":{"background":{"background_type":"image","background_pattern":"type-1","background_image":{"attachment_id":154,"x":0,"y":0,"url":"https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f4a6c6c5db63aa2f18407_Layer-0-1-613x1024.png"},"gradient":"linear-gradient(135deg,rgba(6,147,227,1) 0%,rgb(155,81,224) 100%)","background_repeat":"repeat","background_size":"cover","background_attachment":"scroll","patternColor":{"default":{"color":"#e5e7ea"}},"overlayColor":{"default":{"color":"CT_CSS_SKIP_RULE"}},"backgroundColor":{"default":{"color":"#ffffff"}}},"styles_descriptor":{"styles":{"desktop":"[data-prefix=\"single_page\"] {background-position:0% 0%;background-size:cover;background-color:#ffffff;background-image:url(https:\/\/kidswithspg3a.com\/wp-content\/uploads\/2025\/04\/635f4a6c6c5db63aa2f18407_Layer-0-1-scaled.png);}","tablet":"","mobile":""},"google_fonts":[],"version":6},"has_hero_section":"disabled"},"_links":{"self":[{"href":"https:\/\/kidswithspg3a.com\/tr\/wp-json\/wp\/v2\/pages\/150","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/kidswithspg3a.com\/tr\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/kidswithspg3a.com\/tr\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/kidswithspg3a.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/kidswithspg3a.com\/tr\/wp-json\/wp\/v2\/comments?post=150"}],"version-history":[{"count":16,"href":"https:\/\/kidswithspg3a.com\/tr\/wp-json\/wp\/v2\/pages\/150\/revisions"}],"predecessor-version":[{"id":213,"href":"https:\/\/kidswithspg3a.com\/tr\/wp-json\/wp\/v2\/pages\/150\/revisions\/213"}],"wp:attachment":[{"href":"https:\/\/kidswithspg3a.com\/tr\/wp-json\/wp\/v2\/media?parent=150"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}